Skip to main content

1Provenance card

the boundary, as counts

Sources

4230 with DOI

14 strong · 22 moderate · 6 weak

Compilations

22026-04-25T19:20:50.901Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 10 other runs

Decisions

32last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:30:58.544Z

notice · info card · emergency

Searches

302 with no results

queries and counts on the build

Claims checked

13385 supported

85 supported · 48 not

Correspondence

0received

consent field ships in Phase 4

Edges

382

derivations recorded for this entity

Complete over 42 sources, 2 compilations, and 32 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/caffeine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-28runbrief run
  3. 2026-09-27runbrief run
  4. 2026-09-27runbrief run
  5. 2026-09-27runbrief run
  6. 2026-09-27runbrief run
  7. 2026-09-27runbrief run
  8. 2026-09-23runbrief run
  9. 2026-09-18runbrief run
  10. 2026-09-18runbrief run
  11. 2026-09-18runbrief run
  12. 2026-09-18revisionr1.a1
  13. 2026-09-07srcThe effects of energy drink in combination with alcohol on performance and subjective awareness.
  14. 2026-09-07srcCaffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis.
  15. 2026-09-07srcAcute intentional caffeine overdose treated preemptively with hemodialysis.
  16. 2026-09-07srcEffects of caffeine on anxiety and panic attacks in patients with panic disorder: A systematic review and meta-analysis.
  17. 2026-09-07srcSudden cardiac arrest occurring in temporal proximity to consumption of energy drinks.
  18. 2026-09-07srcLow, but not high, dose caffeine is a readily available probe for adenosine actions.
  19. 2026-09-07srcCaffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.
  20. 2026-09-07srcStructure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.
  21. 2026-09-07srcThe epidemiology of Parkinson's disease: risk factors and prevention.
  22. 2026-09-07srcCharacterization of individuals seeking treatment for caffeine dependence.
  23. 2026-09-07srcCaffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study.
  24. 2026-09-07srcTea, coffee, and caffeine intake and risk of dementia and Alzheimer's disease: a systematic review and meta-analysis of cohort studies.
  25. 2026-09-07srcCaffeine therapy for apnea of prematurity.
  26. 2026-09-07srcThe Effect of Caffeine Consumption and Acute Withdrawal on Resting-State fMRI Brain Connectivity, Mood and Cognition.
  27. 2026-09-07srcCaffeine provokes adverse interactions with MDMA and related psychostimulants: mechanisms and mediators.
  28. 2026-09-07srcArrhythmogenic effects of energy drinks.
  29. 2026-09-07srcRegulatory status of caffeine in the United States.
  30. 2026-09-07srcInternational Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.
  31. 2026-09-07srcInternational society of sports nutrition position stand: caffeine and exercise performance.
  32. 2026-09-07srcAssociation of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort.
  33. 2026-09-07srcExpression and characterization of purinergic receptors in rat middle meningeal artery--potential role in migraine.
  34. 2026-09-07srcPresynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1-A2A Receptor Heteromers
  35. 2026-09-07srcCaffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
  36. 2026-09-07srcScientific Opinion on the safety of caffeine. EFSA 2015.
  37. 2026-09-07srcCaffeine, mental health, and psychiatric disorders.
  38. 2026-09-07srcCaffeine and adenosine.
  39. 2026-09-07srcChronic caffeine consumption prevents memory disturbance in different animal models of memory decline.
  40. 2026-09-07srcPharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing.
  41. 2026-09-07srcPlasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study.
  42. 2026-09-07srcCaffeine Withdrawal
  43. 2026-09-07srcActions of caffeine in the brain with special reference to factors that contribute to its widespread use.
  44. 2026-09-07srcDrug interactions with tobacco smoking. An update.
  45. 2026-09-07srcLow daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (CYP1A2) and omeprazole (CYP2C19).
  46. 2026-09-07srcOxidation of caffeine by CYP1A2: isotope effects and metabolic switching.
  47. 2026-09-07srcFluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.
  48. 2026-09-07srcCaffeine — PubChem CID 2519
  49. 2026-09-07srcCaffeine and sports activity: a review.
  50. 2026-09-07srcBiotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
  51. 2026-09-07srcCaffeine dependence syndrome. Evidence from case histories and experimental evaluations.
  52. 2026-09-07srcA fluvoxamine-caffeine interaction study.
  53. 2026-09-07srcCaffeine history: isolation by Runge 1819, synthesis by Fischer 1895
  54. 2026-09-07srcCaffeine physical properties: melting point, solubility, CAS
  55. 2026-09-04issueIssued emergency
  56. 2026-09-04issueIssued info_card
  57. 2026-09-04issueIssued notice
  58. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  59. 2026-06-04publicationPublication — backfill
  60. 2026-04-25revisionRevision 1
  61. 2026-04-25absenceSearched cross-reference for "Primary ROA discrepancy: seed data says insufflated, evidence review" — no results
  62. 2026-04-25absenceSearched PubMed for "caffeine sleep quality adenosine polysomnography" — no results
  63. 2026-04-25genGeneration — pipeline-v5 · with 1 morepipeline-v5
  64. 2026-04-25rungeneration run
  65. 2026-04-25rungeneration run

The same entries, as forms: six forms.