Caffeine
1Provenance card
the boundary, as counts
Sources
4230 with DOI
14 strong · 22 moderate · 6 weak
Compilations
22026-04-25T19:20:50.901Z
pipeline-v5 · prompt hash not recorded — run predates 2026-09 · 10 other runs
Decisions
32last ruled 2026-06-04
0 awaiting a ruling
Issued documents
42026-10-19T20:30:58.544Z
notice · info card · emergency
Searches
302 with no results
queries and counts on the build
Claims checked
13385 supported
85 supported · 48 not
Correspondence
0received
consent field ships in Phase 4
Edges
382
derivations recorded for this entity
Complete over 42 sources, 2 compilations, and 32 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/caffeine/archive
Timeline
what happened, newest first — claims, searches and artifacts stay inside Build
- 2026-10-19issueIssued info_card
- 2026-09-28runbrief run
- 2026-09-27runbrief run
- 2026-09-27runbrief run
- 2026-09-27runbrief run
- 2026-09-27runbrief run
- 2026-09-27runbrief run
- 2026-09-23runbrief run
- 2026-09-18runbrief run
- 2026-09-18runbrief run
- 2026-09-18runbrief run
- 2026-09-18revisionr1.a1
- 2026-09-07srcThe effects of energy drink in combination with alcohol on performance and subjective awareness.
- 2026-09-07srcCaffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis.
- 2026-09-07srcAcute intentional caffeine overdose treated preemptively with hemodialysis.
- 2026-09-07srcEffects of caffeine on anxiety and panic attacks in patients with panic disorder: A systematic review and meta-analysis.
- 2026-09-07srcSudden cardiac arrest occurring in temporal proximity to consumption of energy drinks.
- 2026-09-07srcLow, but not high, dose caffeine is a readily available probe for adenosine actions.
- 2026-09-07srcCaffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.
- 2026-09-07srcStructure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.
- 2026-09-07srcThe epidemiology of Parkinson's disease: risk factors and prevention.
- 2026-09-07srcCharacterization of individuals seeking treatment for caffeine dependence.
- 2026-09-07srcCaffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study.
- 2026-09-07srcTea, coffee, and caffeine intake and risk of dementia and Alzheimer's disease: a systematic review and meta-analysis of cohort studies.
- 2026-09-07srcCaffeine therapy for apnea of prematurity.
- 2026-09-07srcThe Effect of Caffeine Consumption and Acute Withdrawal on Resting-State fMRI Brain Connectivity, Mood and Cognition.
- 2026-09-07srcCaffeine provokes adverse interactions with MDMA and related psychostimulants: mechanisms and mediators.
- 2026-09-07srcArrhythmogenic effects of energy drinks.
- 2026-09-07srcRegulatory status of caffeine in the United States.
- 2026-09-07srcInternational Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.
- 2026-09-07srcInternational society of sports nutrition position stand: caffeine and exercise performance.
- 2026-09-07srcAssociation of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort.
- 2026-09-07srcExpression and characterization of purinergic receptors in rat middle meningeal artery--potential role in migraine.
- 2026-09-07srcPresynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1-A2A Receptor Heteromers
- 2026-09-07srcCaffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
- 2026-09-07srcScientific Opinion on the safety of caffeine. EFSA 2015.
- 2026-09-07srcCaffeine, mental health, and psychiatric disorders.
- 2026-09-07srcCaffeine and adenosine.
- 2026-09-07srcChronic caffeine consumption prevents memory disturbance in different animal models of memory decline.
- 2026-09-07srcPharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing.
- 2026-09-07srcPlasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study.
- 2026-09-07srcCaffeine Withdrawal
- 2026-09-07srcActions of caffeine in the brain with special reference to factors that contribute to its widespread use.
- 2026-09-07srcDrug interactions with tobacco smoking. An update.
- 2026-09-07srcLow daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (CYP1A2) and omeprazole (CYP2C19).
- 2026-09-07srcOxidation of caffeine by CYP1A2: isotope effects and metabolic switching.
- 2026-09-07srcFluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.
- 2026-09-07srcCaffeine — PubChem CID 2519
- 2026-09-07srcCaffeine and sports activity: a review.
- 2026-09-07srcBiotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults.
- 2026-09-07srcCaffeine dependence syndrome. Evidence from case histories and experimental evaluations.
- 2026-09-07srcA fluvoxamine-caffeine interaction study.
- 2026-09-07srcCaffeine history: isolation by Runge 1819, synthesis by Fischer 1895
- 2026-09-07srcCaffeine physical properties: melting point, solubility, CAS
- 2026-09-04issueIssued emergency
- 2026-09-04issueIssued info_card
- 2026-09-04issueIssued notice
- 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
- 2026-06-04publicationPublication — backfill
- 2026-04-25revisionRevision 1
- 2026-04-25absenceSearched cross-reference for "Primary ROA discrepancy: seed data says insufflated, evidence review" — no results
- 2026-04-25absenceSearched PubMed for "caffeine sleep quality adenosine polysomnography" — no results
- 2026-04-25genGeneration — pipeline-v5 · with 1 morepipeline-v5
- 2026-04-25rungeneration run
- 2026-04-25rungeneration run
The same entries, as forms: six forms.