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1Provenance card

the boundary, as counts

Sources

3728 with DOI

12 strong · 22 moderate · 3 weak

Compilations

12026-04-27T22:14:04.260Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

44last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:30:55.435Z

notice · info card · emergency

Searches

301 with no results

queries and counts on the build

Claims checked

11948 supported

48 supported · 71 not

Correspondence

0received

consent field ships in Phase 4

Edges

361

derivations recorded for this entity

Complete over 37 sources, 1 compilation, and 44 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/buprenorphine/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-07srcBuprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
  3. 2026-09-07srcUse of generally recognized as safe or dietary compounds to inhibit buprenorphine metabolism: potential to improve buprenorphine oral bioavailability
  4. 2026-09-07srcVoriconazole greatly increases the exposure to oral buprenorphine
  5. 2026-09-07srcTreating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option
  6. 2026-09-07srcA role for the mu opioid receptor in the antidepressant effects of buprenorphine
  7. 2026-09-07srcHistory of the discovery, development, and FDA-approval of buprenorphine medications for the treatment of opioid use disorder
  8. 2026-09-07srcCharacterizing withdrawal from long-acting injectable buprenorphine: An observational case series
  9. 2026-09-07srcComparison of toxicity associated with nonmedical use of benzodiazepines with buprenorphine or methadone
  10. 2026-09-07srcHepatotoxicity in a 52-week randomized trial of short-term versus long-term treatment with buprenorphine/naloxone in HIV-negative injection opioid users in China and Thailand
  11. 2026-09-07srcBuprenorphine infrequently found in fatal overdose in New York City
  12. 2026-09-07srcIntranasal buprenorphine alone and in combination with naloxone: Abuse liability and reinforcing efficacy in physically dependent opioid abusers
  13. 2026-09-07srcEffects of buprenorphine on QT intervals in healthy subjects: results of 2 randomized positive- and placebo-controlled trials
  14. 2026-09-07srcPharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder
  15. 2026-09-07srcUrine specimen detection of concurrent nonprescribed medicinal and illicit drug use in patients prescribed buprenorphine
  16. 2026-09-07srcBuprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active
  17. 2026-09-07srcPregnancy Alters CYP- and UGT-Mediated Metabolism of Buprenorphine
  18. 2026-09-07srcBuprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption
  19. 2026-09-07srcThe Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal
  20. 2026-09-07srcArrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration
  21. 2026-09-07srcThe pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers
  22. 2026-09-07srcThe history and pharmacology of buprenorphine: New advances in cats
  23. 2026-09-07srcDevelopment and Verification of a Full Physiologically Based Pharmacokinetic Model for Sublingual Buprenorphine in Healthy Adult Volunteers that Accounts for Nonlinear Bioavailability
  24. 2026-09-07srcMortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies
  25. 2026-09-07srcEvidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology
  26. 2026-09-07srcThe use of buprenorphine in the treatment of drug-resistant depression - an overview of the studies
  27. 2026-09-07srcEvaluation of the Hepatotoxicity of Buprenorphine in Rat Pups Born to an Exposed Mother During Lactation
  28. 2026-09-07srcPopulation pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization
  29. 2026-09-07srcBuprenorphine: The Opioid that Cried 'Partial Agonist'
  30. 2026-09-07srcFlunitrazepam variably alters morphine, buprenorphine, and methadone lethality in the rat
  31. 2026-09-07srcBuprenorphine: new pharmacological aspects
  32. 2026-09-07srcFlunitrazepam does not alter cerebral distribution of buprenorphine in the rat
  33. 2026-09-07srcEffects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes
  34. 2026-09-07srcDoes high-dose buprenorphine cause respiratory depression?: possible mechanisms and therapeutic consequences
  35. 2026-09-07srcBuprenorphine Formulations: Clinical Best Practice Strategies Recommendations for Perioperative Management of Patients Undergoing Surgical or Interventional Pain Procedures
  36. 2026-09-07srcHuman pharmacokinetics of intravenous, sublingual, and buccal buprenorphine
  37. 2026-09-07srcThe effects of buprenorphine in buprenorphine-maintained volunteers
  38. 2026-09-07srcBuprenorphine Controlled Substance Scheduling: US Schedule III, UK Class C Schedule 3, Australia Schedule 8, Canada Narcotic Control Regulations
  39. 2026-09-04issueIssued emergency
  40. 2026-09-04issueIssued info_card
  41. 2026-09-04issueIssued notice
  42. 2026-07-03proposaldependence · taper
  43. 2026-06-04proposal41 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  44. 2026-06-04publicationPublication — backfill
  45. 2026-04-27revisionRevision 1
  46. 2026-04-27absenceSearched PubMed for "buprenorphine intranasal insufflation bioavailability pharmacokinetics abuse" — no results
  47. 2026-04-27genGeneration — pipeline-v5 · with 3 morepipeline-v5
  48. 2026-04-27rungeneration run

The same entries, as forms: six forms.