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Psychedex

Baclofen

β-(4-chlorophenyl)-γ-aminobutyric acid

1Provenance card

the boundary, as counts

Sources

5730 with DOI

23 strong · 17 moderate · 17 weak

Compilations

12026-05-12T04:26:53.719Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

36last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:30:44.682Z

notice · info card · emergency

Searches

232 with no results

queries and counts on the build

Claims checked

11535 supported

35 supported · 80 not

Correspondence

0received

consent field ships in Phase 4

Edges

358

derivations recorded for this entity

Complete over 57 sources, 1 compilation, and 36 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/baclofen/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-10-02srcModulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro: Effect of sub-chronic phencyclidine pretreatment
  3. 2026-10-02srcEffects of baclofen on insular gain anticipation in alcohol-dependent patients - a randomized, placebo-controlled, pharmaco-fMRI pilot trial
  4. 2026-10-02srcEfficacy, Indications, and Safety of Intrathecal Baclofen Pump: A Narrative Review
  5. 2026-10-02srcHypothalamic-pituitary-adrenocortical response in alcohol-dependent patients during baclofen treatment
  6. 2026-10-02srcIntrathecal and Oral Baclofen Use in Adults With Spinal Cord Injury: A Systematic Review of Efficacy in Spasticity Reduction, Functional Changes, Dosing, and Adverse Events
  7. 2026-10-02srcComparative study of therapeutic response to baclofen vs tolperisone in spasticity
  8. 2026-10-02srcHigh-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial
  9. 2026-10-02srcEfficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: A systematic review and meta-analysis
  10. 2026-10-02srcEffects of high-dose baclofen on cue reactivity in alcohol dependence: A randomized, placebo-controlled pharmaco-fMRI study
  11. 2026-10-02srcEffect of centrally and peripherally acting GABA-B agonism on the healthy human cough reflex
  12. 2026-10-02srcClassics in Chemical Neuroscience: Baclofen
  13. 2026-10-02srcA Randomized Double-Blind, Placebo-Controlled, Cross-Over Study Using Baclofen in the Treatment of Rumination Syndrome
  14. 2026-10-02srcNeuropharmacology of alcohol addiction
  15. 2026-10-02srcUse of baclofen for withdrawal in a preterm infant
  16. 2026-10-02srcCryo-EM structures of inactive and active GABA-B receptor
  17. 2026-10-02srcStructural basis of the activation of a metabotropic GABA receptor
  18. 2026-10-02srcPotentially Life-Threatening Interaction between Opioids and Intrathecal Baclofen in Individuals with a Childhood-Onset Neurological Disorder: A Case Series and Review of the Literature
  19. 2026-10-02srcA Randomized, Placebo-Controlled Study of High-Dose Baclofen in Alcohol-Dependent Patients-The ALPADIR Study
  20. 2026-10-02srcBaclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy
  21. 2026-10-02srcEffect of baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease symptoms
  22. 2026-10-02srcBaclofen toxicity in patients with advanced nephropathy: proposal for new labeling
  23. 2026-10-02srcBaclofinding solutions: Baclofen-induced encephalopathy in a peritoneal dialysis patient
  24. 2026-10-02srcProlonged Agitation and Hypotonia due to Baclofen and Tizanidine Overdose Followed by Withdrawal: A Case Report
  25. 2026-10-02srcThe Role of Baclofen in the Treatment of Gastroesophageal Reflux Disease
  26. 2026-10-02srcCentral sleep apnea caused by low dosage of baclofen: a case report
  27. 2026-10-02srcSingle-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  28. 2026-10-02srcThe clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol
  29. 2026-10-02srcNeonatal baclofen withdrawal following intrauterine exposure
  30. 2026-10-02srcBaclofen in alcohol use disorder: An analysis of the data provided by the French "Temporary Recommendation for Use" 2014-2017 cohort
  31. 2026-10-02srcBaclofen-induced neurotoxicity in patients with compromised renal function: Review
  32. 2026-10-02srcDouble-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal
  33. 2026-10-02srcGabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells
  34. 2026-10-02srcClinical and pharmacokinetic aspects of high dose oral baclofen therapy
  35. 2026-10-02srcComplete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician
  36. 2026-10-02srcHaemodialysis clearance of baclofen
  37. 2026-10-02srcEffectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
  38. 2026-10-02srcArbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen
  39. 2026-10-02srcPharmacokinetics of baclofen in spastic patients receiving multiple oral doses
  40. 2026-10-02srcBaclofen and pregnancy: birth defects and withdrawal symptoms
  41. 2026-10-02srcEvidence of a specialized transport mechanism for the intestinal absorption of baclofen
  42. 2026-10-02srcAn intoxication mimicking brain death: baclofen
  43. 2026-10-02srcBaclofen for alcohol withdrawal
  44. 2026-10-02srcRemoval of baclofen with hemodialysis is negligible compared to intact kidney excretion in a pediatric overdose: a case report
  45. 2026-10-02srcHigh-dose baclofen attenuates insula activation during anticipatory anxiety in treatment-seeking alcohol dependant individuals: Preliminary findings from a pharmaco-fMRI study
  46. 2026-10-02srcBaclofen during alcohol detoxification reduces the need for additional diazepam: a randomized placebo-controlled trial
  47. 2026-10-02srcPneumomediastinum: A case report of baclofen toxicity
  48. 2026-10-02srcFood does not affect the bioavailability of baclofen
  49. 2026-10-02srcThe pharmacokinetics of baclofen derived from intestinal infusion
  50. 2026-10-02srcOptimal Dose of Baclofen for the Treatment of Alcohol Use Disorder: A Systematic Review and Dose-Response Meta-analysis
  51. 2026-10-02srcClinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review
  52. 2026-10-02srcPeripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig
  53. 2026-10-02srcSupraventricular tachyarrhythmia associated with baclofen overdose
  54. 2026-10-02srcG-Protein-coupled modulation of presynaptic calcium currents and transmitter release by a GABAB receptor
  55. 2026-10-02srcGABAB receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse
  56. 2026-10-02srcFrance approves Baclocur (baclofen) for alcohol dependence 2020; max dose 80 mg/day
  57. 2026-10-02srcBaclofen pharmacokinetics: Tmax, half-life, protein binding, bioavailability summary
  58. 2026-10-02srcBaclofen - History: A Journey from Antiepileptic Aspirant to Spasticity Mainstay and Beyond
  59. 2026-09-04issueIssued emergency
  60. 2026-09-04issueIssued info_card
  61. 2026-09-04issueIssued notice
  62. 2026-07-03proposaldependence · taper
  63. 2026-06-04proposal33 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  64. 2026-06-04publicationPublication — backfill
  65. 2026-05-12revisionRevision 1
  66. 2026-05-12absenceSearched PubMed for "baclofen history Keberle 1966 chlorophenyl GABA analog synthesis" — no results
  67. 2026-05-12absenceSearched PubMed for "baclofen stereochemistry R-baclofen S-baclofen enantiomer enantioselective" — no results
  68. 2026-05-12genGeneration — pipeline-v5 · with 3 morepipeline-v5
  69. 2026-05-12rungeneration run

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