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1Provenance card

the boundary, as counts

Sources

3836 with DOI

0 strong · 35 moderate · 3 weak

Compilations

12026-04-26T00:41:36.699Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

51last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:30:23.507Z

notice · info card · emergency

Searches

181 with no results

queries and counts on the build

Claims checked

9380 supported

80 supported · 13 not

Correspondence

0received

consent field ships in Phase 4

Edges

306

derivations recorded for this entity

Complete over 38 sources, 1 compilation, and 51 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/a-pvp/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcThe prevalence of new psychoactive substances in biological material - a three-year review of casework in Poland.
  3. 2026-09-24srcCharacterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method.
  4. 2026-09-24srcNeuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs
  5. 2026-09-24srcSelf-administration and behavioral economics of second-generation synthetic cathinones in male rats.
  6. 2026-09-24srcEffects of the new generation α-pyrrolidinophenones on spontaneous locomotor activities in mice, and on extracellular dopamine and serotonin levels in the mouse striatum.
  7. 2026-09-24srcA review of synthetic cathinones emerging in recent years (2019–2022).
  8. 2026-09-24srcStructural and functional perspectives on interactions between synthetic cathinones and monoamine transporters.
  9. 2026-09-24srcPsychoactive 'bath salts' intoxication with methylenedioxypyrovalerone
  10. 2026-09-24srcSynthetic cathinone self-administration in female rats modulates neurotransmitter levels in addiction-related brain regions.
  11. 2026-09-24srcEffects of α-pyrrolidino-phenone cathinone stimulants on locomotor behavior in female rats.
  12. 2026-09-24srcFindings of synthetic cathinones in post-mortem toxicology.
  13. 2026-09-24srcSynthetic cathinones (bath salts)
  14. 2026-09-24srcNew psychoactive versus conventional stimulants - a ten-year review of casework in Hungary.
  15. 2026-09-24srcSex differences in inflammatory cytokine levels following synthetic cathinone self-administration in rats.
  16. 2026-09-24srcRelative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats.
  17. 2026-09-24srcNeuroadaptive changes and behavioral effects after a sensitization regime of MDPV.
  18. 2026-09-24srcRole of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones.
  19. 2026-09-24srcSex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats.
  20. 2026-09-24srcEthanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP).
  21. 2026-09-24srcConditioned place preference with low dose mixtures of α-pyrrolidinopentiophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats.
  22. 2026-09-24srcAlpha pyrrolidinovalerophenone (α-PVP) administration impairs spatial learning and memory in rats through brain mitochondrial dysfunction.
  23. 2026-09-24srcMeasuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay.
  24. 2026-09-24srcStructural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters.
  25. 2026-09-24srcThe abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter.
  26. 2026-09-24srcToxicological Analysis of Cases of Mixed Poisonings with Synthetic Cathinones and Other Drugs of Abuse.
  27. 2026-09-24srcTesting for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urine.
  28. 2026-09-24srcCocaine-like discriminative stimulus effects of alpha-pyrrolidinovalerophenone, methcathinone and their 3,4-methylenedioxy or 4-methyl analogs in rhesus monkeys.
  29. 2026-09-24srcStereoselective neurochemical, behavioral, and cardiovascular effects of α-pyrrolidinovalerophenone enantiomers in male rats.
  30. 2026-09-24srcEarly and Mid-Term Disposition of α-PVP and its unknown Metabolites in Urine and Oral Fluid Through a Multi-Analytical Hyphenated Approach Following a Single Non-Controlled Administration to Healthy Volunteers.
  31. 2026-09-24srcRisk factors for the development of psychotic disorders associated with synthetic cathinones usage.
  32. 2026-09-24srcPharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine.
  33. 2026-09-24srcAlpha-PVP induces the rewarding effect via activating dopaminergic neuron.
  34. 2026-09-24srcHazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays
  35. 2026-09-24srcAcute pharmacological effects of α-PVP in humans: a naturalistic observational study.
  36. 2026-09-24srcMolecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts.
  37. 2026-09-24srcFlakka: New Dangerous Synthetic Cathinone on the Drug Scene.
  38. 2026-09-24srcα-PVP placed in Schedule I (US DEA)
  39. 2026-09-24srcEU Council Decision on control measures for α-PVP
  40. 2026-09-04issueIssued emergency
  41. 2026-09-04issueIssued info_card
  42. 2026-09-04issueIssued notice
  43. 2026-06-04proposal49 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  44. 2026-06-04publicationPublication — backfill
  45. 2026-04-26revisionRevision 1
  46. 2026-04-26absenceSearched ClinicalTrials.gov for "alpha-PVP pyrrolidinopentiophenone stimulant" — no results
  47. 2026-04-26genGeneration — pipeline-v5 · with 2 morepipeline-v5
  48. 2026-04-26rungeneration run

The same entries, as forms: six forms.