7-Hydroxymitragynine

1. 2026-10-06srcIntrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa)
2. 2026-10-06srcSuspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine.
3. 2026-10-06srcEvaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats.
4. 2026-10-06srcDe facto opioids: Characterization of novel 7-hydroxymitragynine and mitragynine pseudoindoxyl product marketing.
5. 2026-10-06srcAn accidental poisoning with mitragynine
6. 2026-10-06srcManagement of acute withdrawal from 7-hydroxymitragynine following high-dose chronic use: A case report.
7. 2026-10-06srcMitragynine and 7-hydroxymitragynine: Bidirectional effects on breathing in rats.
8. 2026-10-06srcEffects of kratom alkaloids on mesolimbic dopamine release.
9. 2026-10-06srcThe medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse
10. 2026-10-06src7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
11. 2026-10-06srcMetabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy.
12. 2026-10-06srcEffects of Itraconazole on Pharmacokinetics of Mitragynine and 7-Hydroxymitragynine in Healthy Volunteers.
13. 2026-10-06srcPhysiologically Based Pharmacokinetic Model for Clinical Translation and Prediction of Drug Interaction of the Major Kratom Alkaloid, Mitragynine
14. 2026-10-06srcSynthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.
15. 2026-10-06srcStudies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids: Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands.
16. 2026-10-06srcChemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
17. 2026-10-06srcKratom as an opioid alternative: harm, or harm reduction? A systematic review of literature.
18. 2026-10-06srcA Descriptive Assessment of Products Containing the Opioid Receptor Stimulator Mitragynine Pseudoindoxyl.
19. 2026-10-06srcFrom kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat.
20. 2026-10-06srcAn update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations.
21. 2026-10-06srcTwo Single-Drug Fatal Intoxications by Mitragynine.
22. 2026-10-06srcCase Control study of mitragynine deaths in Florida.
23. 2026-10-06srcPressure Necrosis Requiring Fasciotomy After Kratom Overdose.
24. 2026-10-06srcA Case of 7-OH Mitragynine Use Requiring Inpatient Medically Managed Withdrawal.
25. 2026-10-06srcSubstance Use Disorder Following Consumption of a Novel Synthetic 7-Hydroxymitragynine Product.
26. 2026-10-06srcComplicating Factors Surrounding Concurrent Use of Kratom and a Novel 7-hydroxymitragynine Product Among a Participant Enrolled in a Kratom Clinical Trial.
27. 2026-10-06srcTreatment of Kratom Use Disorder With Methadone in an Opioid Treatment Program.
28. 2026-10-06srcA Case of 7-Hydroxymitragynine Use Disorder Treated With Buprenorphine.
29. 2026-10-06srcAbuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
30. 2026-10-06srcTranslating Kratom-Drug Interactions: From Bedside to Bench and Back
31. 2026-10-06srcPharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
32. 2026-10-06srcInteractive Effects of mu-Opioid and Adrenergic-alpha2 Receptor Agonists in Rats.
33. 2026-10-06srcPharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
34. 2026-10-06srcTreatment of obsessive compulsive disorder and Kratom dependence with buprenorphine and supportive care.
35. 2026-10-06srcCharacteristics of deaths associated with kratom use
36. 2026-10-06srcChemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
37. 2026-10-06srcHepatotoxicity Induced by the 3Ks: Kava, Kratom and Khat
38. 2026-10-06srcHuman Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder
39. 2026-10-06srcPharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats.
40. 2026-10-06srcKratom induced severe cholestatic liver injury histologically mimicking primary biliary cholangitis: A case report.
41. 2026-10-06srcSevere Early-Onset Withdrawal Following Intentional Use of Mitragynine Pseudoindoxyl: A Case Report and Emerging Clinical Considerations.
42. 2026-10-06srcAntinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
43. 2026-10-06srcAntinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
44. 2026-10-06srcPharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects
45. 2026-10-06srcFDA Takes Steps to Restrict 7-OH Opioid Products Threatening American Consumers
46. 2026-10-06publicationPublication — publishagent-psx
47. 2026-10-06revisionr1.a2
48. 2026-10-02issueIssued info_card
49. 2026-10-02publicationPublication — publishagent-psx
50. 2026-10-02revisionr1.a1
51. 2026-10-02rulingRuling — psx:substance/7-hydroxymitragynine/proposal/article_section_proposals/18b7f7e9-7c2b-445e-a4a2-afffd086ce82founder
52. 2026-10-02rulingRuling — psx:substance/7-hydroxymitragynine/proposal/article_section_proposals/8e07d69b-86ac-4ff4-bb47-4a11c637a3d9founder
53. 2026-09-04issueIssued emergency
54. 2026-09-04issueIssued info_card
55. 2026-09-04issueIssued notice
56. 2026-06-04proposal29 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
57. 2026-06-04publicationPublication — backfill
58. 2026-05-08revisionRevision 1
59. 2026-05-08genGeneration — pipeline-v5 · with 3 morepipeline-v5
60. 2026-05-08rungeneration run

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