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Psychedex
Facts label

4-PrO-DMT Facts

Psychedelic; Entheogen; Hallucinogen; Substituted tryptamine; Serotonin 2A receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Thresholdnot recordedLight5 – 10 mgCommon10 – 25 mgStrong25 – 45 mgHeavy45+ mg

Starts in 20 – 40 minLasts 4 – 8 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
psilocybin; psilocin; 4-AcO-DMT; LSD; mescaline; DMT

Effectslikely at a common dose

Perception
Color alteration; Color enhancement; Geometry; Music enhancement; Visual breathing; Visual drifting; Holotropic state; +28 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; +28 possible, including Nausea, Dizziness, Headache
Thinking
Aesthetic enhancement; Introspection enhancement; Novelty enhancement; +33 possible, including Cognitive impairment, Suggestibility enhancement, Thought loops
Feeling
Emotional enhancement; +7 possible, including Emotional lability, Anxiety
Self
none likely · 14 possible, including Derealization, Depersonalization, Communication suppression
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +4 possible

Who shouldn't take it

Absolute
Lithium; Psychotic spectrum or bipolar I disorder; Pregnancy or breastfeeding; Monoamine oxidase inhibitors (MAOIs)
Relative
Active cardiovascular disease; Borderline personality disorder; SSRIs; Tricyclic antidepressants (TCAs)

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (38)
See full page: psychedex.org/substances/4-pro-dmt
Not graded (4)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/4-pro-dmt · Version r2 · Not medical adviceValues as of
On the printout