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4-PrO-DMT Facts

Psychedelic; Entheogen; Hallucinogen; Substituted tryptamine; Serotonin 2A receptor agonist

Description

4-PrO-DMT (4-propionyloxy-N,N-dimethyltryptamine) is an emerging synthetic psychedelic of the tryptamine class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.[1]

Subjective effects include geometric visual patterns, brightened colors, deepened introspection, ego dissolution, and emotional intensification.[2] The experience is indistinguishable from psilocybin or psilacetin — a warm, inward-turning state shaped more by psychological mindset and surroundings than by the compound itself.

4-PrO-DMT produces no physical dependence, and the psilocin class has a very wide margin between active and dangerous doses.[3][4] The primary risk is psychological — the compound amplifies whatever mindset the person brings, and high doses or psychiatric vulnerability can produce panic or paranoid thinking.

Dose and durationby route · individual sensitivity varies

Oral(mg)
Thresholdnot recordedLight5 – 10 mgCommon10 – 25 mgStrong25 – 45 mgHeavy45+ mg

Starts in 20 – 40 minLasts 4 – 8 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
psilocybin; psilocin; 4-AcO-DMT; LSD; mescaline; DMT

Effectslikely at a common dose

Perception
Color alteration; Color enhancement; Geometry; Music enhancement; Visual breathing; Visual drifting; Holotropic state; +28 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; +28 possible, including Nausea, Dizziness, Headache
Thinking
Aesthetic enhancement; Introspection enhancement; Novelty enhancement; +33 possible, including Cognitive impairment, Suggestibility enhancement, Thought loops
Feeling
Emotional enhancement; +7 possible, including Emotional lability, Anxiety
Self
none likely · 14 possible, including Derealization, Depersonalization, Communication suppression
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +4 possible

Who shouldn't take it

Absolute
Lithium; Psychotic spectrum or bipolar I disorder; Pregnancy or breastfeeding; Monoamine oxidase inhibitors (MAOIs)
Relative
Active cardiovascular disease; Borderline personality disorder; SSRIs; Tricyclic antidepressants (TCAs)

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (38)
See full page: psychedex.org/substances/4-pro-dmt
Not graded (4)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r2 · Not medical advice

References

  1. [1]
    ^Glatfelter GC, Naeem M, Pham DNK, Golen JA, Chadeayne AR, Manke DR, Baumann MH (2023) Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice — ACS Pharmacology & Translational Science doi:10.1021/acsptsci.2c00222
  2. [2]
    ^PsychonautWiki contributors (2024) 4-PrO-DMT Link
  3. [3]
    ^Zhuk O, Jasicka-Misiak I, Poliwoda A, Kazakova A, Godovan VV, Halama M, Wieczorek PP (2015) Research on acute toxicity and the behavioral effects of methanolic extract from psilocybin mushrooms and psilocin in mice — Toxins doi:10.3390/toxins7041018
  4. [4]
    ^Wikipedia contributors (2024) 4-PrO-DMT Link
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