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4-HO-MiPT Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine) — miprocin — is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors, disrupting the brain's sensory filtering and producing the visual and perceptual shifts of a classical psychedelic.[1]

Subjective effects include vivid closed-eye imagery, color enhancement, heightened music enhancement, sexual arousal enhancement, and time alteration. The experience is warm and body-forward — more sensory than psilocin, with less cognitive weight and a distinctive sedative undertow at full doses.[2]

4-HO-MiPT produces no physical dependence — tolerance builds rapidly through downregulation,[3] and no human fatalities have been attributed to it. The main risks are psychological: panic, anxiety, and possible psychosis in predisposed individuals, amplified by combining with MAOIs or tramadol, which causes dangerous serotonin accumulation.[4]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 10 mgCommon10 – 20 mgStrong20 – 30 mgHeavy30+ mg

Starts in 15 – 45 minLasts 4 – 6 hoursAfter-effects 2 – 12 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
psilocybin; psilocin; LSD; DMT; mescaline; 4-HO-MET; 4-AcO-DMT; 4-HO-DiPT

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Music enhancement; Auditory enhancement; Brightness alteration; Geometry; Visual breathing; +29 possible, including Visual haze / noise, Vestibular distortion, Spatial disorientation
Body
Pupil dilation; Wakefulness; Body high; Body scan awareness; +33 possible, including Nausea, Dizziness, Heart rate perception changes
Thinking
Pattern recognition enhancement; Conceptual thinking; Novelty enhancement; Thought connectivity; Aesthetic enhancement; Introspection enhancement; Openness enhancement; +28 possible, including Memory suppression, Cognitive impairment, Decision impairment
Feeling
Emotional enhancement; Euphoria; +7 possible, including Emotional lability, Anxiety, Dysphoria
Self
none likely · 11 possible, including Derealization, Depersonalization
Time
Time alteration; +4 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 6 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy; Concurrent lithium use; Concurrent tramadol use; Concurrent MAOI use
Relative
Cardiovascular disease; Epilepsy; Bipolar disorder; Family history of psychotic disorders

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (19)
MDMA, MDA; Alpha-2 adrenergic receptor antagonist; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/4-ho-mipt
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, et al. (2023) Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential — Nature Communications doi:10.1038/s41467-023-44016-1
  2. [2]
    ^Shulgin (1997) TiHKAL: The Continuation
  3. [3]
    ^de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, Gonzalez-Maeso J (2022) Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice — ACS Chemical Neuroscience doi:10.1021/acschemneuro.2c00170
  4. [4]
    ^Baldo BA (2018) Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects — Archives of Toxicology doi:10.1007/s00204-018-2244-6
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