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Psychedex

1Provenance card

the boundary, as counts

Sources

2725 with DOI

2 strong · 18 moderate · 7 weak

Compilations

12026-05-08T20:18:06.522Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

30last ruled 2026-06-04

0 awaiting a ruling

Issued documents

42026-10-19T20:29:53.184Z

notice · info card · emergency

Searches

241 with no results

queries and counts on the build

Claims checked

9274 supported

74 supported · 18 not

Correspondence

0received

consent field ships in Phase 4

Edges

278

derivations recorded for this entity

Complete over 27 sources, 1 compilation, and 30 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/4-cmc/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-09-24srcPatterns of use and toxicity of new para-halogenated substituted cathinones: 4-CMC (clephedrone), 4-CEC (4-chloroethcatinone) and 4-BMC (brephedrone).
  3. 2026-09-24srcDecoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.
  4. 2026-09-24srcThe newest cathinone derivatives as designer drugs: an analytical and toxicological review
  5. 2026-09-24srcBlood concentrations of a new psychoactive substance 4-chloromethcathinone (4-CMC) determined in 15 forensic cases.
  6. 2026-09-24srcFatal intoxication with U-47700 in combination with other NPS (N-ethylhexedrone, adinazolam, 4-CIC, 4-CMC) confirmed by identification and quantification in autopsy specimens and evidences.
  7. 2026-09-24srcFour Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles.
  8. 2026-09-24srcBehavioral Effects of 4-CMC and 4-MeO-PVP in DBA/2J Mice After Acute and Intermittent Administration and Following Withdrawal from Intermittent 14-Day Treatment.
  9. 2026-09-24srcAnalysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone).
  10. 2026-09-24srcSuicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC.
  11. 2026-09-24srcStability of synthetic cathinones in blood and urine.
  12. 2026-09-24srcMetabolic profile of N-ethylhexedrone, N-ethylpentedrone, and 4-chloromethcathinone in urine samples by UHPLC-QTOF-HRMS.
  13. 2026-09-24srcChallenges encountered in the enantioselective analysis of new psychoactive substances exemplified by clephedrone (4-CMC).
  14. 2026-09-24srcInterpretative problems due to the presence of chloromethcathinone isomers in the biological material from postmortem cases.
  15. 2026-09-24srcSynthetic Cathinones and Their Potential Interactions with Prescription Drugs.
  16. 2026-09-24srcPharmacological characterization of designer cathinones in vitro
  17. 2026-09-24srcNeurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats
  18. 2026-09-24src3-CMC, 4-CMC, and 4-BMC Human Metabolic Profiling: New Major Pathways to Document Consumption of Methcathinone Analogues?
  19. 2026-09-24srcMetabolic stability and metabolite profiling of emerging synthetic cathinones.
  20. 2026-09-24srcPara-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells
  21. 2026-09-24srcNeuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP ("flakka") Derivatives.
  22. 2026-09-24srcGC-MS/MS Determination of N-ethyl Pentedrone and N-ethyl Hexedrone in Oral Fluid and Sweat after Controlled Administration
  23. 2026-09-24srcToxicity of the New Psychoactive Substance (NPS) Clephedrone (4-Chloromethcathinone, 4-CMC): Prediction of Toxicity Using In Silico Methods for Clinical and Forensic Purposes.
  24. 2026-09-24src3-CMC: Acute Effects in Male and Female Mice, Human Intoxication Case Series (Italy, 2014-2025), and Prediction of ADMET Properties.
  25. 2026-09-24srcOral Fluid Concentrations and Pharmacological Effects of Clephedrone and Methylone in Humans.
  26. 2026-09-24srcThe Effect of Selected Cathinones on Natural Cell Membranes: Microelectrophoretic Methods.
  27. 2026-09-24srcSchedules of Controlled Substances: Placement of 4-Chloromethcathinone in Schedule I
  28. 2026-09-24srcSubstance Details 4-CMC
  29. 2026-09-04issueIssued emergency
  30. 2026-09-04issueIssued info_card
  31. 2026-09-04issueIssued notice
  32. 2026-06-04proposal28 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  33. 2026-06-04publicationPublication — backfill
  34. 2026-05-08revisionRevision 1
  35. 2026-05-08absenceSearched ClinicalTrials.gov for "clephedrone 4-CMC synthetic cathinone" — no results
  36. 2026-05-08genGeneration — pipeline-v5 · with 9 morepipeline-v5
  37. 2026-05-08rungeneration run

The same entries, as forms: six forms.