Skip to main content
Psychedex
Facts label

3-MeO-PCMo Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 50 mgLight100 – 200 mgCommon200 – 300 mgStrong300 – 400 mgHeavy400+ mg

Starts in 60 – 120 minLasts 5 – 6 hoursAfter-effects 120 – 180 min

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Low
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
ketamine; PCP; 3-MeO-PCP; dextromethorphan; methoxetamine

Effectslikely at a common dose

Perception
none likely · 25 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Motor control impairment; +26 possible, including Nystagmus (eye wobbles), Dizziness, Insomnia
Thinking
Cognitive impairment; +28 possible, including Memory suppression, Analysis suppression, Confusion
Feeling
none likely · 9 possible, including Mania, Anxiety, Emotional lability
Self
none likely · 10 possible, including Depersonalization, Derealization, Ego inflation
Time
Time alteration; +2 possible, including Temporal disorientation
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Concurrent CNS depressant use; Psychotic disorders
Relative
Cardiovascular disease; Seizure disorders; Bipolar disorder; Hepatic impairment; CYP2D6 poor metabolizer status; Pregnancy and lactation

Combinations61 recorded

Lethal (1)
GHB, GBL
Dangerous (32)
Benzodiazepines; Buprenorphine, Kratom; Naltrexone; NSAIDs; THC; Amphetamines; Anticholinergics; Antihistamines; Atypical antipsychotics; Benzodiazepines, Barbiturates; Buspirone; Clonidine, Guanfacine; Dopamine agonists; Gabapentin, Pregabalin; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; and 8 more, see full page
Caution (24)
See full page: psychedex.org/substances/3-meo-pcmo
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/3-meo-pcmo · Version r1.a1 · Not medical adviceValues as of
On the printout