3-MeO-PCMo Facts
Dissociative;
Description
3-MeO-PCMo (4-[1-(3-methoxyphenyl)cyclohexyl]morpholine) is a synthetic dissociative of the arylcyclohexylamine class. It blocks glutamate signaling in the brain,[1] producing the disconnection from body and surroundings that defines the dissociative experience.
Subjective effects include depersonalization, derealization, cognitive disconnection, pain suppression, and amnesia. The experience builds slowly — a warm, motionless body sensation with gradual mental detachment, softer and more drawn out than most dissociatives.[2]
3-MeO-PCMo carries moderate addiction and dependence potential.[2] The dominant risk is combining it with alcohol or other depressants — every documented death involving the closely related 3-MeO-PCP involved that combination, through additive respiratory depression.[3][4]
Dose and durationby route · individual sensitivity varies
Starts in 60 – 120 minLasts 5 – 6 hoursAfter-effects 120 – 180 min
Body and dependence
- Acute toxicity
- Moderate
- Chronic toxicity
- Low
- Physical dependence
- Moderate
- Psychological dependence
- Moderate
- Withdrawal
- Mild
- Compulsive redosing
- Moderate
Tolerance
- Builds
- Moderate
- Fully resets after
- 10.5 days
- Carries over to
- ketamine;
PCP; 3-MeO-PCP; dextromethorphan; methoxetamine
Effectslikely at a common dose
- Perception
- none likely · 25 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
- Body
- Motor control impairment;
+26 possible, including Nystagmus (eye wobbles), Dizziness, Insomnia - Thinking
- Cognitive impairment;
+28 possible, including Memory suppression, Analysis suppression, Confusion - Feeling
- none likely · 9 possible, including Mania, Anxiety, Emotional lability
- Self
- none likely · 10 possible, including Depersonalization, Derealization, Ego inflation
- Time
- Time alteration;
+2 possible, including Temporal disorientation - Awareness
- none likely · 2 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
- Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
- Complete loss of coordination — cannot stand or walk safely
- Vomiting while incapacitated (choking / aspiration risk)
- Very high blood pressure; fast heart rate
- Slow or shallow breathing at high doses (especially mixed with depressants)
- Unconsciousness; rarely, seizures
What to do
- Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
- Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
- Stay with them and reassure calmly; keep the environment quiet
- If breathing is slow/shallow or they are unresponsive, call emergency services
- Do not let them wander; do not leave them alone
- Be ready to give rescue breaths / CPR
Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, Westphal F, Brandt SD, Adejare A (2018) Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues — Drug Testing and Analysis doi:10.1002/dta.2213
- [2]
- [3]^Johansson A, Lindstedt D, Roman M, Thelander G, Nielsen EI, Lennborn U, Sandler H, Rubertsson S, Ahlner J, Kronstrand R, Kugelberg FC (2017) A non-fatal intoxication and seven deaths involving the dissociative drug 3-MeO-PCP — Forensic Science International doi:10.1016/j.forsciint.2017.02.034
- [4]^de Jong LAA, Olyslager EJH, Duijst WLJM (2019) The risk of emerging new psychoactive substances: The first fatal 3-MeO-PCP intoxication in The Netherlands — Journal of Forensic and Legal Medicine doi:10.1016/j.jflm.2019.05.011