Skip to main content

25I-NBOH

4-iodo-2,5-dimethoxy-N-(2-hydroxybenzyl)phenethylamine

1Provenance card

the boundary, as counts

Sources

2927 with DOI

1 strong · 22 moderate · 6 weak

Compilations

12026-05-08T23:35:52.712Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

28last ruled 2026-06-04

0 awaiting a ruling

Issued documents

62026-10-19T20:29:12.382Z

notice · info card · emergency

Searches

152 with no results

queries and counts on the build

Claims checked

7868 supported

68 supported · 10 not

Correspondence

0received

consent field ships in Phase 4

Edges

245

derivations recorded for this entity

Complete over 29 sources, 1 compilation, and 28 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/25i-nboh/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued emergency
  2. 2026-10-19issueIssued info_card
  3. 2026-10-19issueIssued notice
  4. 2026-09-07src25CN-NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor
  5. 2026-09-07srcCharacterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH
  6. 2026-09-07srcIdentification of thermolabile positional isomers of N-(2-hydroxybenzyl)-2-(dimethoxyphenyl)ethanamines (NBOH series) using chromatography and mass spectrometry methods
  7. 2026-09-07srcThe Selective 5HT2A Receptor Agonist, 25CN-NBOH Exerts Excitatory and Inhibitory Cellular Actions on Mouse Medial Prefrontal Cortical Neurons
  8. 2026-09-07srcPharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens
  9. 2026-09-07srcOpioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects
  10. 2026-09-07srcSevere 25E-NBOH intoxication associated with MDPHP intake: a case report, metabolism study, and literature review
  11. 2026-09-07src25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil
  12. 2026-09-07srcNeurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
  13. 2026-09-07srcThe selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics
  14. 2026-09-07srcIdentification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays
  15. 2026-09-07srcPostmortem detection of 25I-NBOMe in fluids and tissues determined by HPLC-MS/MS from a traumatic death
  16. 2026-09-07srcSimultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography-tandem mass spectrometry: A targeted approach
  17. 2026-09-07srcCorrelation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species
  18. 2026-09-07srcDiscovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
  19. 2026-09-07srcInvestigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
  20. 2026-09-07srcStructure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists.
  21. 2026-09-07srcN-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues
  22. 2026-09-07srcIdentification of 5-HT2A receptor signaling pathways associated with psychedelic potential
  23. 2026-09-07srcBehavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation
  24. 2026-09-07srcBad trip due to 25I-NBOMe: a case report from the EU project SPICE II plus
  25. 2026-09-07src2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOME): A Harmful Hallucinogen Review
  26. 2026-09-07srcFatal Intoxications with 25B-NBOMe and 25I-NBOMe in Indiana During 2014.
  27. 2026-09-07srcA Case Review of the First Analytically Confirmed 25I-NBOMe-Related Death in Washington State
  28. 2026-09-07srcNBOMes-Highly Potent and Toxic Alternatives of LSD
  29. 2026-09-07srcAcute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice
  30. 2026-09-07srcPsilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner
  31. 2026-09-07srcMolecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists
  32. 2026-09-07src25I-NBOH Legal Status - Erowid NBOMe Series Vault
  33. 2026-09-04issueIssued emergency
  34. 2026-09-04issueIssued info_card
  35. 2026-09-04issueIssued notice
  36. 2026-06-04proposal26 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  37. 2026-06-04publicationPublication — backfill
  38. 2026-05-08revisionRevision 1
  39. 2026-05-08absenceSearched DEA press release / Federal Register for "DEA scheduling NBOMe NBOH synthetic phenethylamine" — no results
  40. 2026-05-08absenceSearched ClinicalTrials.gov for "25I-NBOH NBOH psychedelic" — no results
  41. 2026-05-08genGeneration — pipeline-v5 · with 3 morepipeline-v5
  42. 2026-05-08rungeneration run

The same entries, as forms: six forms.