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Psychedex

25E-NBOH

4-ethyl-2,5-dimethoxy-N-(2-hydroxybenzyl)phenethylamine

1Provenance card

the boundary, as counts

Sources

2422 with DOI

2 strong · 20 moderate · 2 weak

Compilations

12026-05-07T23:19:49.670Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

32last ruled 2026-06-04

0 awaiting a ruling

Issued documents

62026-10-19T20:29:09.789Z

notice · info card · emergency

Searches

181 with no results

queries and counts on the build

Claims checked

7056 supported

56 supported · 14 not

Correspondence

0received

consent field ships in Phase 4

Edges

231

derivations recorded for this entity

Complete over 24 sources, 1 compilation, and 32 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/25e-nboh/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued emergency
  2. 2026-10-19issueIssued info_card
  3. 2026-10-19issueIssued notice
  4. 2026-09-07src25CN-NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor
  5. 2026-09-07srcPharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens
  6. 2026-09-07srcBehavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function
  7. 2026-09-07srcHallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl)ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice
  8. 2026-09-07srcSerotonin toxicity of serotonergic psychedelics
  9. 2026-09-07srcRadiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
  10. 2026-09-07src25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil
  11. 2026-09-07srcIdentification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH
  12. 2026-09-07srcCardiovascular safety of psychedelic medicine: current status and future directions
  13. 2026-09-07srcA quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain
  14. 2026-09-07srcMetabolic characterization of 25X-NBOH and 25X-NBOMe phenethylamines based on UHPLC-Q-Exactive Orbitrap MS in human liver microsomes.
  15. 2026-09-07srcMetabolic profile of 25E-NBOH in human liver microsomes, rat urine, and fungus Cunninghamella elegans
  16. 2026-09-07srcReceptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)
  17. 2026-09-07srcDiscovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
  18. 2026-09-07srcTolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice
  19. 2026-09-07srcStructure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists.
  20. 2026-09-07srcDARK Classics in Chemical Neuroscience: NBOMes
  21. 2026-09-07srcThe psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents
  22. 2026-09-07srcPsychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
  23. 2026-09-07srcElectroanalytical identification of 25I-NBOH and 2C-I via differential pulse voltammetry: a rapid and sensitive screening method to avoid misidentification
  24. 2026-09-07srcLocomotor and discriminative stimulus effects of NBOH hallucinogens in rodents
  25. 2026-09-07srcNBOMes-Highly Potent and Toxic Alternatives of LSD
  26. 2026-09-07srcBeware of blotting paper hallucinogens: severe toxicity with NBOMes
  27. 2026-09-07src25E-NBOH
  28. 2026-09-04issueIssued emergency
  29. 2026-09-04issueIssued info_card
  30. 2026-09-04issueIssued notice
  31. 2026-06-04proposal30 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  32. 2026-06-04publicationPublication — backfill
  33. 2026-05-07revisionRevision 1
  34. 2026-05-07absenceSearched ClinicalTrials.gov for "25E-NBOH NBOH psychedelic phenethylamine" — no results
  35. 2026-05-07genGeneration — pipeline-v5 · with 2 morepipeline-v5
  36. 2026-05-07rungeneration run

The same entries, as forms: six forms.