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Psychedex
Facts label

25D-NBOMe Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Dose and durationby route · individual sensitivity varies

Sublingual(µg)
Threshold< 300 µgLight300 – 800 µgCommon800 – 1000 µgStrong1000 – 1200 µgHeavy1200+ µg

Starts in 20 – 40 minLasts 4 – 8 hoursAfter-effects 1 – 4 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Negligible
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Rapid
Fully resets after
10 days
Carries over to
LSD; psilocybin; psilocin; mescaline; 2C-D; 2C-B; 2C-E; 2C-I; DOB; DOC; DOM; 25I-NBOMe; 25C-NBOMe; 25B-NBOMe

Effectslikely at a common dose

Perception
Color alteration; Color enhancement; Geometry; Tracers; Visual breathing; Visual drifting; Visual morphing; +27 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; Stimulation; Wakefulness; +26 possible, including Excessive sweating, Insomnia, Muscle tension
Thinking
none likely · 30 possible, including Analysis suppression, Cognitive dysphoria, Cognitive impairment
Feeling
none likely · 10 possible, including Anxiety, Paranoia, Emotional lability
Self
none likely · 8 possible, including Derealization, Communication suppression, Depersonalization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Pre-existing cardiac arrhythmia or prolonged QT interval; Concurrent QT-prolonging medications; Seizure disorders; Concurrent serotonergic medications; Concurrent lithium use
Relative
Cardiovascular disease; History of psychotic disorders; Hepatic impairment; Hypokalemia or hypomagnesemia

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/25d-nbome
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/25d-nbome · Version r1 · Not medical adviceValues as of
On the printout