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25D-NBOMe Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Description

25D-NBOMe is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain,[1][2] producing the visual and cognitive shifts characteristic of classical psychedelics.

Subjective effects include brightened colors, visual patterning, introspective thought, muscle tension, and a persistent cardiovascular awareness — elevated heart rate and peripheral tension. The experience is closest to LSD in perceptual character, but the body competes with the mind for attention throughout.

Physical dependence is not documented, but animal studies show 25D-NBOMe activates dopamine reward circuits,[3] and tolerance builds rapidly after each use.[4] It disrupts a heart channel that controls normal rhythm,[5] and the broader NBOMe class is linked to seizures, dangerous overheating, and organ failure.

Dose and durationby route · individual sensitivity varies

Sublingual(µg)
Threshold< 300 µgLight300 – 800 µgCommon800 – 1000 µgStrong1000 – 1200 µgHeavy1200+ µg

Starts in 20 – 40 minLasts 4 – 8 hoursAfter-effects 1 – 4 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Negligible
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Rapid
Fully resets after
10 days
Carries over to
LSD; psilocybin; psilocin; mescaline; 2C-D; 2C-B; 2C-E; 2C-I; DOB; DOC; DOM; 25I-NBOMe; 25C-NBOMe; 25B-NBOMe

Effectslikely at a common dose

Perception
Color alteration; Color enhancement; Geometry; Tracers; Visual breathing; Visual drifting; Visual morphing; +27 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Pupil dilation; Stimulation; Wakefulness; +26 possible, including Excessive sweating, Insomnia, Muscle tension
Thinking
none likely · 30 possible, including Analysis suppression, Cognitive dysphoria, Cognitive impairment
Feeling
none likely · 10 possible, including Anxiety, Paranoia, Emotional lability
Self
none likely · 8 possible, including Derealization, Communication suppression, Depersonalization
Time
none likely · 3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Pre-existing cardiac arrhythmia or prolonged QT interval; Concurrent QT-prolonging medications; Seizure disorders; Concurrent serotonergic medications; Concurrent lithium use
Relative
Cardiovascular disease; History of psychotic disorders; Hepatic impairment; Hypokalemia or hypomagnesemia

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/25d-nbome
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Johnson RA, Janowsky A (2018) Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors. — Biochemical Pharmacology doi:10.1016/j.bcp.2018.09.024
  2. [2]
    ^Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, et al. (2023) Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential — Nature Communications doi:10.1038/s41467-023-44016-1
  3. [3]
    ^Lee JG, Hur KH, Hwang SB, Lee S, Lee SY, Jang CG (2023) Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System — ACS Chemical Neuroscience doi:10.1021/acschemneuro.3c00196
  4. [4]
    ^Wojtas A, Gołembiowska K (2023) Molecular and Medical Aspects of Psychedelics. — International Journal of Molecular Sciences doi:10.3390/ijms25010241
  5. [5]
    ^Yoon KS, Yun J, Kim YH, Shin J, Kim SJ, Seo JW, Hyun SA, Suh SK, Cha HJ (2019) 2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) induce adverse cardiac effects in vitro and in vivo — Toxicology Letters doi:10.1016/j.toxlet.2019.01.004
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