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Psychedex

25C-NBOH

4-chloro-2,5-dimethoxy-N-(2-hydroxybenzyl)phenethylamine

1Provenance card

the boundary, as counts

Sources

3227 with DOI

1 strong · 22 moderate · 9 weak

Compilations

12026-05-07T22:52:58.951Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

33last ruled 2026-06-04

0 awaiting a ruling

Issued documents

62026-10-19T20:29:06.626Z

notice · info card · emergency

Searches

162 with no results

queries and counts on the build

Claims checked

7663 supported

63 supported · 13 not

Correspondence

0received

consent field ships in Phase 4

Edges

250

derivations recorded for this entity

Complete over 32 sources, 1 compilation, and 33 decisions.Not here: the private journal (never).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/25c-nboh/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued emergency
  2. 2026-10-19issueIssued info_card
  3. 2026-10-19issueIssued notice
  4. 2026-09-07src25CN-NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor
  5. 2026-09-07srcCharacterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH
  6. 2026-09-07srcDesigner drugs: mechanism of action and adverse effects
  7. 2026-09-07src25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil
  8. 2026-09-07srcIdentification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH
  9. 2026-09-07srcNeurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors.
  10. 2026-09-07srcIdentification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays
  11. 2026-09-07srcSynthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists
  12. 2026-09-07srcA fatal poisoning involving 25C-NBOMe.
  13. 2026-09-07srcDeath after 25C-NBOMe and 25H-NBOMe consumption.
  14. 2026-09-07srcMetabolic fate and detectability of 25B-NBOMe and 25C-NBOMe in human and rat urine by GC-MS, LC-MSn, and LC-HR-MS/MS approaches.
  15. 2026-09-07srcAn innovative approach for selective and robust screening of NBOHs, NBOMes, and LSD in forensic samples using a 3D-Printed electrochemical double cell
  16. 2026-09-07src2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) induce adverse cardiac effects in vitro and in vivo
  17. 2026-09-07src2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH) induce adverse effects on the cardiovascular system
  18. 2026-09-07srcDARK Classics in Chemical Neuroscience: NBOMes
  19. 2026-09-07srcSynthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT2A/2C Agonists
  20. 2026-09-07srcN-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues
  21. 2026-09-07srcIdentification of 5-HT2A receptor signaling pathways associated with psychedelic potential
  22. 2026-09-07srcBehavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation
  23. 2026-09-07src25I-NBOMe, a phenethylamine derivative, induces adverse cardiovascular effects in rodents: possible involvement of p21 (CDC42/RAC)-activated kinase 1
  24. 2026-09-07srcDetection of 25C-NBOMe in Three Related Cases
  25. 2026-09-07srcTwo cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe.
  26. 2026-09-07srcCase series: toxicity from 25B-NBOMe--a cluster of N-bomb cases.
  27. 2026-09-07srcNBOMes-Highly Potent and Toxic Alternatives of LSD
  28. 2026-09-07srcNeurochemical and Behavioral Profiling in Male and Female Rats of the Psychedelic Agent 25I-NBOMe.
  29. 2026-09-07srcA Comprehensive Analysis of Legislative Strategies for New Psychoactive Substances: The Brazilian Panorama
  30. 2026-09-07srcSerotonin toxicity: a practical approach to diagnosis and treatment
  31. 2026-09-07srcTramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review
  32. 2026-09-07srcNBOMe: new potent hallucinogens--pharmacology, analytical methods, toxicities, fatalities: a review
  33. 2026-09-07src25C-NBOH (hydrochloride) reference standard
  34. 2026-09-07srcUNODC Laboratory and Scientific Section - 25C-NBOH substance details
  35. 2026-09-07srcHome Office Circular 008/2014: Changes to the Misuse of Drugs Act 1971 - Control of NBOMe compounds
  36. 2026-09-04issueIssued emergency
  37. 2026-09-04issueIssued info_card
  38. 2026-09-04issueIssued notice
  39. 2026-06-04proposal31 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  40. 2026-06-04publicationPublication — backfill
  41. 2026-05-07revisionRevision 1
  42. 2026-05-07absenceSearched ClinicalTrials.gov for "NBOH 25C phenethylamine psychedelic" — no results
  43. 2026-05-07absenceSearched PubMed for "25C-NBOH serotonin receptor psychedelic pharmacology" — no results
  44. 2026-05-07genGeneration — pipeline-v5 · with 2 morepipeline-v5
  45. 2026-05-07rungeneration run

The same entries, as forms: six forms.