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Psychedex

1Provenance card

the boundary, as counts

Sources

4325 with DOI

14 strong · 19 moderate · 10 weak

Compilations

12026-05-09T03:16:40.291Z

pipeline-v5 · prompt hash not recorded — run predates 2026-09

Decisions

33last ruled 2026-06-04

1 awaiting a ruling

Issued documents

42026-10-19T20:28:28.293Z

notice · info card · emergency

Searches

202 with no results

queries and counts on the build

Claims checked

14396 supported

96 supported · 47 not

Correspondence

0received

consent field ships in Phase 4

Edges

394

derivations recorded for this entity

Complete over 43 sources, 1 compilation, and 33 decisions.Not here: the private journal (never); 1 proposal awaiting a ruling (listed as pending only).Working material — drafts, discards, unsupported claims — is listed below and readable on the working page.Cite: psychedex.org/substances/1-4-butanediol/archive

Timeline

what happened, newest first — claims, searches and artifacts stay inside Build

  1. 2026-10-19issueIssued info_card
  2. 2026-10-02srcDrug-drug interaction between diclofenac and gamma-hydroxybutyric acid
  3. 2026-10-02srcButanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole
  4. 2026-10-02srcSedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
  5. 2026-10-02srcInhibition of 1,4-butanediol metabolism in human liver in vitro
  6. 2026-10-02srcInpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review
  7. 2026-10-02srcBaclofen and gamma-hydroxybutyrate withdrawal
  8. 2026-10-02srcFatal poisoning in drug addicts in the Nordic countries in 2012
  9. 2026-10-02srcThe distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: comparison with baclofen
  10. 2026-10-02srcNarcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials
  11. 2026-10-02src1,4-Butanediol overdose mimicking toxic alcohol exposure
  12. 2026-10-02srcSevere gamma-hydroxybutyrate withdrawal with delirium, hemodynamic lability, and rhabdomyolysis: A case series
  13. 2026-10-02srcPhenobarbital to manage severe gamma-hydroxybutyrate withdrawal: A case series
  14. 2026-10-02srcA case of severe and prolonged gamma-hydroxybutyrate (GHB) withdrawal syndrome successfully managed with a slow benzodiazepine and baclofen taper
  15. 2026-10-02srcChemsex and antiretroviral prescribing in an HIV cohort in Brighton, UK
  16. 2026-10-02srcGamma hydroxybutirate use for sexual assault
  17. 2026-10-02srcThe Neurobiological Mechanisms of Gamma-Hydroxybutyrate Dependence and Withdrawal and Their Clinical Relevance: A Review
  18. 2026-10-02srcEvidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology
  19. 2026-10-02srcClinical review: Major consequences of illicit drug consumption
  20. 2026-10-02srcManagement of pharmaceutical and recreational drug poisoning
  21. 2026-10-02srcγ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology
  22. 2026-10-02srcCurrent Insights on the Impact of Gamma-Hydroxybutyrate (GHB) Abuse
  23. 2026-10-02srcGHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome
  24. 2026-10-02srcCognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review
  25. 2026-10-02srcThe clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol
  26. 2026-10-02srcTreatment of Poorly Responsive Gamma-Hydroxybutyrate Withdrawal With Baclofen: A Case Report
  27. 2026-10-02srcGamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors
  28. 2026-10-02srcEvidence for a G protein-coupled gamma-hydroxybutyric acid receptor
  29. 2026-10-02srcRole of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid
  30. 2026-10-02srcThe role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies
  31. 2026-10-02srcSpecific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice
  32. 2026-10-02srcThe Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam
  33. 2026-10-02srcSignificance of gamma-hydroxybutyric acid in the brain
  34. 2026-10-02srcThe Xyrem risk management program
  35. 2026-10-02srcGHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier
  36. 2026-10-02srcFatalities associated with the use of gamma-hydroxybutyrate and its analogues in Australasia
  37. 2026-10-02srcPharmacokinetics and excretion of gamma-hydroxybutyrate (GHB) in healthy subjects
  38. 2026-10-02srcClinical pharmacology of 1,4-butanediol and gamma-hydroxybutyrate after oral 1,4-butanediol administration to healthy volunteers
  39. 2026-10-02srcEffects of 1,4-butanediol administration on oxidative stress in rat brain: study of the neurotoxicity of GHB in vivo
  40. 2026-10-02srcGHB, GBL and 1,4-BD addiction
  41. 2026-10-02srcWithdrawal syndrome following chronic use of gamma-hydroxybutyric acid (GHB)
  42. 2026-10-02src1,4 Butanediol, gamma-hydroxybutyric acid and ethanol: relationships and interactions
  43. 2026-10-02srcBinding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist
  44. 2026-10-02srcLegal Status of 1,4-Butanediol: UK Misuse of Drugs Act (Class C, 2009), Federal Analogue Act (US), Australian border-controlled drug (2024)
  45. 2026-09-04issueIssued emergency
  46. 2026-09-04issueIssued info_card
  47. 2026-09-04issueIssued notice
  48. 2026-07-03proposaldependence · taper
  49. 2026-06-04proposal30 value proposals approved togetherone review action inferred from a shared reviewer and instant — the graph records one activity per proposal
  50. 2026-06-04publicationPublication — backfill
  51. 2026-05-09revisionRevision 1
  52. 2026-05-09absenceSearched DEA PDF — no results
  53. 2026-05-09absenceSearched PubMed for "GHB GABA-B receptor binding affinity Ki EC50" — no results
  54. 2026-05-09genGeneration — pipeline-v5 · with 3 morepipeline-v5
  55. 2026-05-09rungeneration run

The same entries, as forms: six forms.