Xylazine Facts
Depressant;
Dose and durationby route · individual sensitivity varies
Intravenous
No dose recorded for this route. The timings are not a dose guide.
Starts in 1 – 5 minLasts 30 – 120 minAfter-effects 2 – 12 hours
Body and dependence
- Acute toxicity
- Critical
- Chronic toxicity
- High
- Physical dependence
- High
- Psychological dependence
- Moderate
- Withdrawal
- Moderate · medical supervision
- Compulsive redosing
- Low
Tolerance
- Builds
- Moderate
- Fully resets after
- Not recorded
- Carries over to
- mu opioid agonists (supraspinal);
delta opioid agonists (supraspinal); fentanyl
Effectslikely at a common dose
- Perception
- none likely · 6 possible, including Spatial disorientation, Vestibular distortion, Visual acuity suppression
- Body
- Motor control impairment;
Muscle relaxation; Pain suppression; Physical fatigue; Pupil constriction; Respiratory depression; Sedation; Vasoconstriction; +9 possible, including Abnormal heartbeat, Dizziness, Temperature dysregulation - Thinking
- Cognitive fatigue;
Cognitive impairment; Confusion; Decision impairment; Focus suppression; Information processing suppression; Motivation suppression; Thought deceleration; +6 possible, including Language suppression, Memory suppression, Compulsive redosing urge - Feeling
- none likely · 7 possible, including Dysphoria, Anhedonia, Depression
- Self
- Sociability suppression;
Social disconnection; +4 possible, including Communication suppression, Craving, Depersonalization - Time
- none likely · 2 possible, including Temporal disorientation
Who shouldn't take it
Absolute
Opioid co-administration;
Relative
Pre-existing cardiovascular disease;
Combinations60 recorded
Dangerous (22)
Alpha-2 adrenergic receptor antagonist;
Caution (27)
See full page: psychedex.org/substances/xylazine
Not graded (11)
Not listed never means safe.
Seek help immediately if
No emergency profile is recorded for this substance. Not recorded never means no risk.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
psychedex.org/substances/xylazine · Version r1 · Not medical adviceValues as of