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Theobromine Facts

Stimulant; Purine alkaloid; Adenosine receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 50 mgLight100 – 200 mgCommon200 – 400 mgStrong500 – 700 mgHeavy850+ mg

Starts in 30 – 60 minLasts 6 – 10 hoursAfter-effects 0 – 2 hours

Body and dependence

Acute toxicity
Negligible
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
None
Fully resets after
Not recorded
Carries over to
caffeine

Effectslikely at a common dose

Body
none likely · 5 possible, including Insomnia

Who shouldn't take it

Relative
Pre-existing tachyarrhythmias; Impaired glucose tolerance / diabetes; Pregnancy; Concurrent CYP1A2 inhibitor therapy

Combinations61 recorded

Dangerous (18)
Amphetamines; Ephedrine, Pseudoephedrine; Local anesthetics; Stimulants; CBD; GHB, Baclofen; GHB, GBL; Ibogaine; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Synthetic cannabinoids; Salvia, Ibogaine
Caution (29)
See full page: psychedex.org/substances/theobromine
Not graded (14)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/theobromine · Version r1 · Not medical adviceValues as of
On the printout