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Psychedex
Facts label

Tetrahydrocannabutol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3 mgLight3 – 12 mgCommon12 – 30 mgStrong30 – 70 mgHeavy70+ mg

Starts in 30 – 60 minLasts 4 – 8 hours

Also recorded: Inhaled. See full page: psychedex.org/substances/tetrahydrocannabutol

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
Low
Psychological dependence
Low
Withdrawal
Mild
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
21 days
Carries over to
Δ9-THC; Δ8-THC; THCP; THCV; THCH; synthetic cannabinoids

Effectslikely at a common dose

Perception
none likely · 21 possible, including Spatial disorientation, Vestibular distortion, Visual acuity suppression
Body
Body high; Dry mouth; +18 possible, including Heart rate perception changes, Motor control impairment, Abnormal heartbeat
Thinking
none likely · 32 possible, including Cognitive impairment, Memory suppression, Thought disorganization
Feeling
none likely · 9 possible, including Anxiety, Paranoia, Dysphoria
Self
none likely · 9 possible, including Craving, Derealization, Communication suppression
Time
Time alteration; +2 possible, including Temporal disorientation
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Psychotic disorders (schizophrenia, schizoaffective disorder); Pregnancy and lactation
Relative
Unstable cardiovascular disease; First-degree family history of psychotic disorders; Hepatic impairment; Concurrent anticoagulant therapy (warfarin, coumarins); Narrow-therapeutic-index CYP3A4 substrates (tacrolimus, cyclosporine)

Combinations60 recorded

Dangerous (7)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Opioids; Salvia, Ibogaine; Synthetic cannabinoids; Ibogaine
Caution (34)
See full page: psychedex.org/substances/tetrahydrocannabutol
Not graded (19)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/tetrahydrocannabutol · Version r1 · Not medical adviceValues as of
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