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Tetrahydrocannabiphorol Facts

Cannabinoid; Cannabinoid; Cannabinoid CB1 receptor full agonist

Description

THCP (tetrahydrocannabiphorol) is a cannabinoid of the dibenzopyran class. It resembles Δ9-THC but carries a longer carbon chain that dramatically increases its potency. It activates cannabinoid receptors roughly 33 times more strongly than THC,[1] producing intense sedation and a powerful cannabis-like high.

Subjective effects include heavy sedation, intense euphoria, appetite stimulation, altered time perception, and marked short-term memory loss. The experience resembles cannabis but amplified — heavier, more disorienting, and capable of overwhelming cognitive function at doses where THC would cause only mild intoxication.[2]

THCP carries elevated dependence and acute toxicity risk relative to THC. It drives cannabinoid receptors to their maximum — unlike THC, which has a built-in ceiling — predicting faster tolerance and a lower threshold for severe reactions including seizure.[3][4]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 0.15 mgLight0.15 – 0.5 mgCommon0.5 – 1.5 mgStrong1.5 – 3 mgHeavy5+ mg

Starts in 30 – 90 minLasts 4 – 10 hoursAfter-effects 4 – 24 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
3 weeks
Carries over to
Δ9-THC; Δ8-THC; HHC; HHCP; synthetic cannabinoids

Effectslikely at a common dose

Perception
none likely · 22 possible, including Spatial disorientation, Visual acuity suppression, Visual haze / noise
Body
Body high; Dry mouth; Motor control impairment; Sedation; +24 possible, including Heart rate perception changes, Abnormal heartbeat, Dehydration sensation
Thinking
Cognitive impairment; +31 possible, including Decision impairment, Memory suppression, Analysis suppression
Feeling
none likely · 11 possible, including Anxiety, Paranoia, Emotional lability
Self
none likely · 14 possible, including Communication suppression, Craving, Depersonalization
Time
Time alteration; +3 possible, including Temporal disorientation
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Unstable cardiovascular disease; Personal or family history of psychotic disorders (schizophrenia, schizoaffective disorder)
Relative
Bipolar disorder; History of cannabis use disorder; Hepatic impairment; Pregnancy and lactation; Adolescence (under 25); Concurrent narrow-TI CYP2C9/CYP3A4 substrates (warfarin, tacrolimus, cyclosporine)

Combinations60 recorded

Dangerous (27)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Opioids; Alpha-2 adrenergic receptor antagonist; Atypical antipsychotics; Benzodiazepines; Caffeine; Cannabis; Cannabis, THC; Clonidine, Guanfacine; Ephedrine, Pseudoephedrine; Gabapentin, Pregabalin; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, MDA; NDRIs (Wellbutrin); Salvia, Ibogaine; SNRIs; SSRIs; THC; and 3 more, see full page
Caution (21)
See full page: psychedex.org/substances/tetrahydrocannabiphorol
Not graded (12)
Not listed never means safe.

Seek help immediately if

Natural cannabis rarely causes a medical emergency — "greening out" is: pale/sweaty skin, dizziness, nausea or vomiting, anxiety or panic, rapid heartbeat, feeling faint — and usually passes with rest.

Seek emergency help for these — far more likely with synthetic cannabinoids ("spice" / K2):

  • Seizures
  • Severe chest pain; very fast or irregular heartbeat
  • Unresponsiveness or extreme drowsiness
  • Severe agitation, aggression, or psychosis
  • Repeated vomiting; difficulty breathing

What to do

  1. Sit or lie them down somewhere calm, cool, and quiet
  2. Reassure them — cannabis panic and "greening out" pass with time
  3. Offer sips of water; a little sugar can help if they feel faint
  4. Recovery position if nauseated, drowsy, or vomiting
  5. Stay with them and monitor
  6. For seizures, chest pain, unresponsiveness, or severe agitation, call emergency services

Natural cannabis "greening out" resolves with rest, calm, and time, with no lasting harm. Synthetic cannabinoids are unpredictable and can cause seizures, cardiac events, kidney injury, and severe agitation that needs emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1.a1 · Not medical advice

References

  1. [1]
    ^Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G (2019) A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol — Scientific Reports doi:10.1038/s41598-019-56785-1
  2. [2]
    ^Caprari C, Ferri E, Vandelli MA, Citti C, Cannazza G (2024) An emerging trend in Novel Psychoactive Substances (NPSs): designer THC — Journal of Cannabis Research doi:10.1186/s42238-024-00226-y
  3. [3]
    ^Fattore L, Fratta W (2011) Beyond THC: The New Generation of Cannabinoid Designer Drugs — Frontiers in Behavioral Neuroscience doi:10.3389/fnbeh.2011.00060
  4. [4]
    ^Janssens LK, Van Uytfanghe K, Williams JB, Hering KW, Iula DM, Stove CP (2024) Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays - and how this matters for the harm potential of seized drugs — Archives of Toxicology doi:10.1007/s00204-024-03769-4
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