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Psychedex
Facts label

Scopolamine Facts

Deliriant; Substituted tropane; Muscarinic acetylcholine receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Thresholdnot recordedLightnot recordedCommon0.3 – 0.6 mgStrongnot recordedHeavynot recorded

Starts in 30 – 45 minLasts 4 – 6 hours

Also recorded: Nasal spray · Transdermal · Intravenous · Subcutaneous. See full page: psychedex.org/substances/scopolamine

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Negligible
Withdrawal
Moderate
Compulsive redosing
Negligible

Tolerance

Builds
None
Fully resets after
Not recorded
Carries over to
atropine; diphenhydramine; other anticholinergic agents

Effectslikely at a common dose

Perception
Visual acuity suppression; +14 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Abnormal heartbeat; Dry mouth; Nausea suppression; Pupil dilation; +13 possible, including Dehydration sensation, Dizziness, Heart rate perception changes
Thinking
Cognitive impairment; Confusion; Decision impairment; Focus suppression; Information processing suppression; Memory suppression; +12 possible, including Analysis suppression, Suggestibility enhancement, Thought disorganization
Feeling
none likely · 6 possible, including Anxiety, Dysphoria, Paranoia
Self
none likely · 9 possible, including Communication suppression, Social disconnection, Depersonalization
Time
none likely · 2 possible, including Temporal disorientation
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Hypersensitivity to belladonna alkaloids; Angle-closure glaucoma
Relative
Myasthenia gravis; Cognitive impairment in elderly; Significant hepatic impairment; Benign prostatic hyperplasia / urinary retention; Significant renal impairment; Severe preeclampsia; Children; Co-administration with other anticholinergics; Co-administration with CNS depressants; CYP3A inhibitors (grapefruit, ketoconazole, erythromycin); MRI with transdermal patch

Combinations60 recorded

Dangerous (18)
Amphetamines; Antihistamines; Antipsychotics; Atypical antipsychotics; Buprenorphine, Kratom; GHB, GBL; MDMA, MDA; Naltrexone; Opioids; Ephedrine, Pseudoephedrine; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; NDRIs (Wellbutrin); Salvia, Ibogaine; SSRIs; Stimulants
Caution (35)
See full page: psychedex.org/substances/scopolamine
Not graded (7)
Not listed never means safe.

Seek help immediately if

Deliriants are genuinely dangerous — treat any strong reaction as a medical emergency.

  • True delirium — confused, disoriented, doesn't know what's real or recognize people/danger
  • Vivid, frightening hallucinations; agitation or aggression
  • Hot, flushed, dry skin and high body temperature
  • Dilated pupils; blurred vision
  • Fast heartbeat; inability to urinate
  • Seizures; unconsciousness

What to do

  1. Call emergency services — deliriant poisoning (especially datura / belladonna) can be life-threatening
  2. Keep them physically safe — they may not know what they're doing and can badly injure themselves; remove hazards and stay with them
  3. Do not leave them alone; do not try to reason them out of it — they are delirious
  4. If overheating, cool the body
  5. Recovery position if drowsy, vomiting, or unconscious; be ready for rescue breaths / CPR

Deliriant effects are long (many hours to more than a day) and the person is not safe or in control throughout. The main dangers are self-injury during delirium, overheating, and — for potent anticholinergics like datura — cardiac and central-nervous-system toxicity. Medical monitoring is often needed.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/scopolamine · Version r1 · Not medical adviceValues as of
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