Salvinorin A

===Harm reduction=== ====Forms & Identification= === Salvinorin A cannot be detected by standard alkaloid [[glossary:reagent-kit|reagent tests]] (Marquis, Mecke, Simon's){{cite|doi=10.1055/s-2007-981566|anchor=9c9173a5}}{{cite|doi=10.3390/ph14020116|anchor=f03e3666}}. For extract products, concentration labels (5×, 10×, etc.) are unregulated and unreliable — actual salvinorin A content may differ significantly from what is stated. When using extract products, treat every new batch as an unknown [[glossary:potency]] and start with the smallest possible amount. ==== Set & Setting= === The salvinorin A experience is exceptionally sensitive to environment. Onset is near-instantaneous, leaving no time to adjust once the dose is inhaled. A quiet, familiar, physically safe space is essential — remove sharp objects, open flames, and anything breakable from the immediate area. A reclining position (sitting or lying down) is strongly recommended, as motor control is lost rapidly at [[glossary:active-dose|active doses]]. A sober, trusted [[glossary:sitter]] is not optional for smoked or vaporized use. The sitter's role is to prevent physical harm (falls, contact with hot surfaces, wandering) and to provide calm, minimal verbal [[glossary:reassurance]] if the user shows [[glossary:distress]]. The sitter should not attempt to physically restrain the user unless there is immediate danger of serious injury. {{Guideline}} ==== Guidelines= === * Test every new batch at the lowest possible dose — potency varies between products and sources * Use a reclining position — lie down or sit in a supported chair before inhaling * Always have a sober sitter present who understands the [[glossary:rapid-onset]] and short duration * Clear the environment of hazards: open flames, sharp objects, hard surfaces within falling distance, bodies of water * Secure all smoking materials — have the sitter hold the pipe or vaporizer after the dose is inhaled, as the user will lose motor control * Start with plain leaf before trying extracts — move to concentrated extracts only after establishing individual [[glossary:sensitivity]] * Allow at least 30 minutes of quiet time following the experience before standing, walking, or leaving the setting * Do not combine with other psychoactive substances — [[glossary:drug-interaction|drug interactions]] are uncharacterized {{/Guideline}} {{Emergency}} ==== Emergency Response= === '''Recognizing an emergency:''' Most salvinorin A experiences, even distressing ones, resolve within 20 minutes. Seek emergency help if the person attempts [[glossary:self-harm]], becomes physically combative, does not return to baseline [[glossary:awareness]] within 30 minutes, sustains a fall or burn injury, or shows signs of a psychotic break (persistent [[effect:delusions]], inability to recognize surroundings or people after effects should have resolved). '''Immediate steps:''' * 1. Ensure physical safety — gently guide the person away from hazards. Do not physically restrain unless there is immediate danger of serious injury. * 2. Stay calm and speak in short, quiet sentences. Do not attempt to reason with someone in peak dissociation. * 3. If the person is lying down and unresponsive, place them in the [[glossary:recovery-position]]. * 4. Call emergency services if the person is injured, if distress does not resolve within 30 minutes, or if [[glossary:psychosis|psychotic symptoms]] persist. '''What to tell the dispatcher:''' Name the substance (salvinorin A or ''Salvia divinorum''), approximate amount and form used, time of use, and current symptoms. [[glossary:good-samaritan-law|Good Samaritan laws]] in many jurisdictions protect people who call for help. '''Reversal agent:''' Naltrexone and [[substance:naloxone]] fully reverse all effects of salvinorin A{{cite|doi=10.1093/ijnp/pyw016|anchor=ce409517}}. Emergency medical personnel carrying naloxone can administer it if needed. {{/Emergency}} {{Aftercare}} ==== Aftercare & Integration= === The salvinorin A experience is often disorienting and difficult to process. Many users report difficulty articulating what happened, and [[effect:amnesia]] for portions of the experience is common. Allow time in a quiet setting before attempting to describe or analyze the experience. Journaling soon after return to baseline — even fragmented impressions — can help anchor memories before they fade. Discussing the experience with the sitter or a trusted person in the hours or days following may aid processing. If the experience produced lasting distress, [[effect:confusion]] about reality, or persistent [[effect:anxiety]], professional support from a [[glossary:therapist]] experienced with altered states is appropriate. {{/Aftercare}} {{Recovery}} ==== Recovery & Support= === Compulsive salvinorin A use is rare — the experience is more commonly abandoned than sought repeatedly{{cite|doi=10.1080/02791072.2016.1179376|anchor=2991c21b}}. No [[glossary:physical-dependence]] or [[glossary:withdrawal]] has been documented. If a pattern of repeated use develops despite negative experiences, this may reflect an underlying psychological need rather than pharmacological compulsion, and professional support is warranted. The Fireside Project ([[substance_class:psychoactive/psychedelic]] [[glossary:peer-support]] line), MAPS [[glossary:integration]] resources, and local [[index:harm-reduction|harm reduction]] organizations can provide guidance and [[glossary:referral|referrals]]. {{/Recovery}}

===Harm reduction=== ====Forms & Identification= === Salvinorin A cannot be detected by standard alkaloid [[glossary:reagent-kit|reagent tests]] (Marquis, Mecke, Simon's){{cite|doi=10.1055/s-2007-981566|anchor=ebb1e624}}{{cite|doi=10.3390/ph14020116|anchor=bb065ddf}}. Extract concentration labels (5×, 10×, etc.) are unregulated — actual content may differ significantly from stated values. Treat every new batch as an unknown [[glossary:potency]] and start with the smallest possible amount. ==== Set & Setting= === The salvinorin A experience is exceptionally sensitive to environment, and onset is near-instantaneous — there is no time to adjust once the dose is inhaled. A quiet, familiar, physically safe space is essential. Remove sharp objects, open flames, and anything breakable from the immediate area. A reclining position is strongly recommended, as motor control is lost rapidly at [[glossary:active-dose|active doses]]. A sober, trusted [[glossary:sitter]] is not optional for smoked or vaporized use. The sitter's role is to prevent physical harm — falls, contact with hot surfaces, wandering — and to provide calm, minimal verbal [[glossary:reassurance]] if [[glossary:distress]] arises. Physical restraint should only occur if there is immediate danger of serious injury. {{Guideline}} ==== Guidelines= === * Test every new batch at the lowest possible dose — potency varies between products and sources * Use a reclining position — lie down or sit in a supported chair before inhaling * Always have a sober sitter present who understands the [[glossary:rapid-onset]] and short duration * Clear the environment of hazards: open flames, sharp objects, hard surfaces within falling distance, bodies of water * Secure all smoking materials — have the sitter hold the pipe or vaporizer after the dose is inhaled, as motor control will be lost * Start with plain leaf before trying extracts — move to concentrated extracts only after establishing individual [[glossary:sensitivity]] * Allow at least 30 minutes of quiet time after the experience before standing, walking, or leaving the setting * Do not combine with other psychoactive substances — [[glossary:drug-interaction|drug interactions]] are uncharacterized {{/Guideline}} {{Emergency}} ==== Emergency Response= === '''Recognizing an emergency:''' Most salvinorin A experiences, even distressing ones, resolve within 20 minutes. Seek emergency help if the person attempts [[glossary:self-harm]], becomes physically combative, does not return to baseline [[glossary:awareness]] within 30 minutes, sustains a fall or burn injury, or shows signs of a psychotic break (persistent [[effect:delusions]], inability to recognize surroundings or people after effects should have resolved). '''Immediate steps:''' * 1. Ensure physical safety — gently guide the person away from hazards. Do not physically restrain unless there is immediate danger of serious injury. * 2. Stay calm and speak in short, quiet sentences. Do not attempt to reason with someone in peak dissociation. * 3. If the person is lying down and unresponsive, place them in the [[glossary:recovery-position]]. * 4. Call emergency services if the person is injured, if distress does not resolve within 30 minutes, or if [[glossary:psychosis|psychotic symptoms]] persist. '''What to tell the dispatcher:''' Name the substance (salvinorin A or ''Salvia divinorum''), approximate amount and form used, time of use, and current symptoms. [[glossary:good-samaritan-law|Good Samaritan laws]] in many jurisdictions protect people who call for help. '''Reversal agent:''' Naltrexone and [[substance:naloxone]] fully reverse all effects of salvinorin A{{cite|doi=10.1093/ijnp/pyw016|anchor=5886d0d3}}. Emergency personnel carrying naloxone can administer it if needed. {{/Emergency}} {{Aftercare}} ==== Aftercare & Integration= === The salvinorin A experience is often difficult to articulate, and [[effect:amnesia]] for portions is common. Allow time in a quiet setting before attempting to describe or analyze what happened. Journaling soon after returning to baseline — even fragmented impressions — can help anchor memories before they fade. If the experience produced lasting distress, [[effect:confusion]] about reality, or persistent [[effect:anxiety]], professional support from a [[glossary:therapist]] experienced with altered states is appropriate. {{/Aftercare}} {{Recovery}} ==== Recovery & Support= === Compulsive salvinorin A use is rare — the experience is more commonly abandoned than sought repeatedly{{cite|doi=10.1080/02791072.2016.1179376|anchor=7237904f}}. No [[glossary:physical-dependence]] or [[glossary:withdrawal]] has been documented. If a pattern of repeated use develops despite negative experiences, professional support is warranted. The Fireside Project ([[substance_class:psychoactive/psychedelic]] [[glossary:peer-support]] line), MAPS [[glossary:integration]] resources, and local [[index:harm-reduction|harm reduction]] organizations can provide guidance and [[glossary:referral|referrals]]. {{/Recovery}}