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Psychedex
Facts label

Rolicyclidine Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 1 mgLight2 – 3 mgCommon4 – 8 mgStrong8 – 12 mgHeavy14+ mg

Starts in 20 – 90 minLasts 6 – 12 hoursAfter-effects 4 – 12 hours

Also recorded: Smoked · Insufflated. See full page: psychedex.org/substances/rolicyclidine

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
phencyclidine; ketamine; eticyclidine; tenocyclidine; 3-MeO-PCP; 3-MeO-PCE; deschloroketamine

Effectslikely at a common dose

Perception
Touch suppression; Proprioceptive distortion; Spatial disorientation; Vestibular distortion; +14 possible, including Visual acuity suppression, Visual haze / noise, Double vision
Body
Pain suppression; Dizziness; Motor control impairment; Body schema distortion; Nystagmus (eye wobbles); +28 possible, including Nausea, Temperature dysregulation, Excessive sweating
Thinking
Analysis suppression; Memory suppression; Thought disorganization; Cognitive impairment; Confusion; Decision impairment; Focus suppression; Information processing suppression; +19 possible, including Language suppression, Compulsive redosing urge, Cognitive dysphoria
Feeling
none likely · 12 possible, including Anxiety, Emotional lability, Paranoia
Self
Depersonalization; Derealization; +7 possible, including Social disconnection, Ego inflation, Communication suppression
Time
Time alteration; Temporal disorientation; +2 possible

Who shouldn't take it

Absolute
Psychotic disorders; Pregnancy
Relative
Cardiovascular disease; Respiratory compromise; Epilepsy; Bipolar disorder; Hepatic impairment

Combinations63 recorded

Lethal (4)
GHB, GBL; Ibogaine; Tramadol; αMT
Dangerous (36)
Amphetamines; Benzodiazepines; Buprenorphine, Kratom; Ephedrine, Pseudoephedrine; MDMA, Amphetamines; Naltrexone; NDRIs (Wellbutrin); NRIs; NSAIDs; Opioids; THC; Anticholinergics; Antihistamines; Atypical antipsychotics; Benzodiazepines, Barbiturates; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; DXM; Gabapentin, Pregabalin; GHB, Baclofen; Ketamine, DXM, PCP; Lithium; and 12 more, see full page
Caution (20)
See full page: psychedex.org/substances/rolicyclidine
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/rolicyclidine · Version r1 · Not medical adviceValues as of
On the printout