PRO-LAD Facts
Psychedelic;
Description
PRO-LAD (6-propyl-6-nor-lysergic acid diethylamide) is a synthetic psychedelic of the lysergamide class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.[1]
Subjective effects include intellectual clarity, humor enhancement, tingling and numbness throughout the body, moderate geometric visual patterns, and strong responsiveness to music.[2] The experience is shorter and more grounded than LSD — lucid and analytically clear, with a prominent physical dimension that sets it apart from LSD's more visually saturated character.[3]
PRO-LAD produces no physical dependence, and acute physical toxicity is expected to be low by analogy with LSD.[1] The primary danger is psychological — panic, acute psychosis in predisposed individuals, and rarely persistent visual disturbances; combining it with lithium or MAOIs presents serious additional risk.
Dose and durationby route · individual sensitivity varies
Starts in 30 – 45 minLasts 6 – 8 hoursAfter-effects 2 – 4 hours
Body and dependence
- Acute toxicity
- Negligible
- Chronic toxicity
- Negligible
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 14 days
- Carries over to
- LSD;
psilocybin; mescaline; AL-LAD; ETH-LAD; 1P-LSD; DMT; 2C-B
Effectslikely at a common dose
- Perception
- Color enhancement;
Visual drifting; Color alteration; Geometry; Visual breathing; +28 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise - Body
- Pupil dilation;
Body scan awareness; +29 possible, including Insomnia, Temperature dysregulation, Muscle tension - Thinking
- Novelty enhancement;
Introspection enhancement; Aesthetic enhancement; +30 possible, including Decision impairment, Suggestibility enhancement, Thought loops - Feeling
- Emotional enhancement;
+7 possible, including Emotional lability, Anxiety, Paranoia - Self
- none likely · 10 possible, including Derealization, Communication suppression, Depersonalization
- Time
- Time alteration;
+3 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^abPassie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008) The pharmacology of lysergic acid diethylamide: a review — CNS Neuroscience and Therapeutics doi:10.1111/j.1755-5949.2008.00059.x
- [2]
- [3]