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Psychedex
Facts label

Pregabalin Facts

Depressant; Anxiolytic; Gabapentinoid; Alpha-2-delta voltage-gated calcium channel blocker

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 25 mgLight25 – 75 mgCommon75 – 300 mgStrong300 – 600 mgHeavy600+ mg

Starts in 15 – 30 minLasts 5 – 8 hoursAfter-effects 2 – 6 hours

Also recorded: Rectal. See full page: psychedex.org/substances/pregabalin

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate · medical supervision
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
Not recorded
Carries over to
gabapentin

Effectslikely at a common dose

Perception
none likely · 9 possible, including Visual acuity suppression, Double vision, Spatial disorientation
Body
Pain suppression; +10 possible, including Dizziness, Motor control impairment
Thinking
none likely · 11 possible, including Cognitive impairment, Information processing suppression, Analysis suppression
Feeling
none likely · 3 possible
Self
none likely · 5 possible, including Craving

Who shouldn't take it

Absolute
Concurrent opioid use; Severe renal impairment; Pregnancy
Relative
Heart failure; Concurrent benzodiazepine or Z-drug use; Substance use disorder history; Concurrent alcohol use

Combinations60 recorded

Dangerous (11)
Benzodiazepines, Barbiturates; Buprenorphine, Kratom; Clonidine, Guanfacine; Opioids; SNRIs; Alpha-2 adrenergic receptor antagonist; Benzodiazepines; GHB, Baclofen; GHB, GBL; Ketamine, DXM, PCP; Synthetic cannabinoids
Caution (26)
See full page: psychedex.org/substances/pregabalin
Not graded (23)
Not listed never means safe.

Seek help immediately if

  • Extreme drowsiness — can't stay awake or be roused
  • Confusion, slurred speech, severe loss of coordination
  • Slow, shallow, or irregular breathing
  • Unconsciousness / unresponsive; limp, floppy body
  • Blue lips or fingertips
  • Vomiting while sedated (choking / aspiration risk)
  • Cold, clammy skin; weak pulse

What to do

  1. Try to wake them — shout, firm sternal rub
  2. If unresponsive or breathing is impaired, call emergency services
  3. Place them in the recovery position — critical, they can choke on vomit
  4. Monitor breathing continuously; be ready to give rescue breaths / CPR
  5. Never leave them alone to "sleep it off"
  6. Do not give other drugs, stimulants, or more depressants

Most depressant overdoses resolve with airway protection, breathing support, and monitoring. The danger is respiratory depression and choking on vomit — sharply worse when combined with opioids or alcohol. GHB/GBL overdoses often involve sudden deep unconsciousness and may self-resolve, but airway protection is essential.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/pregabalin · Version r1 · Not medical adviceValues as of
On the printout