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Psychedex
Facts label

PMMA Facts

Stimulant; Entactogen; Substituted amphetamine; Monoamine oxidase inhibitor

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 25 mgLight40 – 80 mgCommon100 – 120 mgStrong120 – 150 mgHeavy150+ mg

Starts in 45 – 90 minLasts 3 – 5 hoursAfter-effects 2 – 4 hours

Body and dependence

Acute toxicity
Critical
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Moderate
Fully resets after
Not recorded
Carries over to
MDMA; PMA; amphetamine

Effectslikely at a common dose

Perception
none likely · 4 possible
Body
Stimulation; Temperature dysregulation; Excessive sweating; +23 possible, including Dehydration sensation, Abnormal heartbeat, Vasoconstriction
Thinking
none likely · 5 possible, including Compulsive redosing urge, Cognitive impairment, Confusion
Feeling
none likely · 4 possible, including Anxiety
Self
none likely · 6 possible
Time
none likely · 1 possible

Who shouldn't take it

Absolute
MAOI therapy; SSRI/SNRI therapy; CYP2D6 poor metabolizer status; Pregnancy
Relative
Pre-existing cardiovascular disease; Hypertension; Hepatic impairment; Renal impairment; Hyperthyroidism

Combinations60 recorded

Lethal (6)
MAOIs; MDMA, Amphetamines; MDMA, MDA; Psychedelics; SNRIs; Stimulants
Dangerous (32)
5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Anticholinergics; Atypical antipsychotics; Caffeine; Dopamine agonists; Ephedrine, Pseudoephedrine; Local anesthetics; NDRIs (Wellbutrin); NRIs; Opioids; Antihistamines; Antipsychotics; Benzodiazepines, Barbiturates; Buspirone; Cannabis; Clonidine, Guanfacine; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; L-Tyrosine; Lithium; and 8 more, see full page
Caution (19)
See full page: psychedex.org/substances/pmma
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Overheating / very high body temperature — heavy sweating, then hot dry skin (the leading cause of MDMA deaths, worse when dancing in hot venues)
  • Muscle rigidity, jaw clenching, tremor, or twitching (possible serotonin syndrome)
  • Fast, pounding heartbeat; chest pain
  • Agitation, confusion; seizures
  • Hyponatremia (water intoxication) — headache, confusion, drowsiness, vomiting, and seizures from drinking too much water
  • Nausea/vomiting; collapse or unconsciousness

What to do

  1. Move them somewhere cool and help them cool down — overheating is the main danger
  2. Sip water to stay hydrated but DO NOT overdrink — roughly a cup (250 ml) per hour if active; too much water can be deadly (hyponatremia)
  3. Get them to rest and stop dancing
  4. For overheating, seizures, chest pain, muscle rigidity/tremor, confusion, or unresponsiveness, call emergency services
  5. Recovery position if drowsy or vomiting; stay with them
  6. Be ready to give rescue breaths / CPR

Most resolve with cooling, rest, sensible hydration, and time. The life-threatening dangers are hyperthermia, serotonin syndrome, and hyponatremia (too much water) — each a medical emergency, not something to wait out.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/pmma · Version r1 · Not medical adviceValues as of
On the printout