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Entity
Phenobarbital
PSX-0297
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Common namesPhenobarbital, Phenobarbitone, Luminal, Phenobarb
Substitutive namephenylethylbarbiturate
PsychoactiveDepressant
+1 more
SedativeChemicalBarbiturate
PharmacologicalGABA-A receptor positive allosteric modulator
Threshold
< 25 mg
Light
50 – 100 mg
Common
100 – 150 mg
Strong
150 – 300 mg
Onset
15 – 60 min
Come up
1 – 2 hours
Peak
4 – 6 hours
Offset
12 – 24 hours
After effects
1 – 48 hours
Total:4 – 6 hours
minlowmodhigh
Acute
Chronic
Physical
Psych.
Withdrawalnot assessed
Dosage varies by body weight, tolerance & metabolism · Not medical advice · Terms
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Phenobarbital
Effects (20)
Perception
Visual acuity suppressionBody
SedationMotor control impairmentMuscle relaxationDizzinessAbnormal heartbeatRespiratory depressionSeizure threshold reductionTactile euphoriaSexual arousal suppressionThinking
Cognitive euphoriaThought decelerationAnalysis suppressionAmnesiaLanguage suppressionCompulsive redosing urgeDelusions of sobrietySelf
DisinhibitionDependence
extremely physically and psychologically addictive
experience reports
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First-person accounts of subjective effects, timing, and outcomes — submitted for harm reduction.
Last updated Mar 17, 2026Report an issue