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Entity
Pentobarbital
PSX-0293
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Common namesPentobarbital, pentobarbitone, Nembutal
Substitutive name5-ethyl-5-(1-methylbutyl)barbituric acid
PsychoactiveDepressant
ChemicalBarbiturate
PharmacologicalGABA-A receptor positive allosteric modulator
Threshold
< 25 mg
Light
50 – 100 mg
Common
100 – 200 mg
Strong
200 – 300 mg
Onset
15 – 60 min
Peak
1 – 3 hours
Offset
1 – 2 hours
After effects
1 – 36 hours
Total:4 – 6 hours
minlowmodhigh
Acute
Chronic
Physical
Psych.
Withdrawalnot assessed
Dosage varies by body weight, tolerance & metabolism · Not medical advice · Terms
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Pentobarbital
Effects (21)
Perception
Visual acuity suppressionBody
Tactile euphoriaSexual arousal suppressionPain suppressionSedationMotor control impairmentMuscle relaxationDizzinessRespiratory depressionAbnormal heartbeatSeizure threshold reductionThinking
Cognitive euphoriaThought decelerationAnalysis suppressionAmnesiaLanguage suppressionCompulsive redosing urgeDelusions of sobrietySelf
DisinhibitionDependence
extremely physically and psychologically addictive
experience reports
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First-person accounts of subjective effects, timing, and outcomes — submitted for harm reduction.
Last updated Mar 17, 2026Report an issue