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Psychedex
Facts label

Peganum harmala Facts

Psychedelic; Indole alkaloid; Monoamine oxidase inhibitor

Dose and duration

No dose or duration recorded for any route.

Body and dependence

Acute toxicity
Not assessed
Chronic toxicity
Not assessed
Physical dependence
Not assessed
Psychological dependence
Not assessed
Withdrawal
Not assessed
Compulsive redosing
Not assessed

Tolerance

Not recorded.

Who shouldn't take it

None recorded. Not listed never means safe to take.

Combinations60 recorded

Lethal (6)
Amphetamines; MDMA, Amphetamines; MDMA, MDA; Psychedelics; SNRIs; Stimulants
Dangerous (32)
Alpha-2 adrenergic receptor antagonist; Buspirone; Ephedrine, Pseudoephedrine; Local anesthetics; NRIs; Opioids; SSRIs; 5-HTP, Tryptophan; Anticholinergics; Antihistamines; Antipsychotics; Atypical antipsychotics; Benzodiazepines, Barbiturates; Caffeine; Cannabis; Clonidine, Guanfacine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; L-Tyrosine; Lithium; and 8 more, see full page
Caution (18)
See full page: psychedex.org/substances/peganum-harmala
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/peganum-harmala · Version r1 · Not medical adviceValues as of