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Psychedex
Facts label

O-PCE Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 2 mgLight3 – 8 mgCommon8 – 15 mgStrong15 – 25 mgHeavy25+ mg

Starts in 20 – 40 minLasts 3 – 6 hoursAfter-effects 4 – 48 hours

Also recorded: Insufflated. See full page: psychedex.org/substances/o-pce

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
None recorded
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
14 days
Carries over to
ketamine; deschloroketamine; methoxetamine; PCP; DXM; nitrous oxide

Effectslikely at a common dose

Perception
Touch suppression; Spatial disorientation; +34 possible, including Double vision, Visual acuity suppression, Vestibular distortion
Body
Motor control impairment; Pain suppression; Body high; Nystagmus (eye wobbles); +28 possible, including Dizziness, Insomnia, Nausea
Thinking
Cognitive impairment; +29 possible, including Memory suppression, Confusion, Decision impairment
Feeling
Euphoria; +11 possible, including Empathy suppression, Anhedonia, Anxiety
Self
Derealization; +10 possible, including Depersonalization, Social disconnection, Communication suppression
Time
Time alteration; +4 possible, including Temporal disorientation
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Epilepsy; Psychotic disorders; Pregnancy; Concurrent MAOI use
Relative
Uncontrolled hypertension; Coronary artery disease; Concurrent SNRI use; Concurrent CNS depressant use

Combinations60 recorded

Lethal (4)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Local anesthetics
Dangerous (35)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; MDMA, Amphetamines; Naltrexone; NRIs; NSAIDs; Stimulants; THC; Anticholinergics; Antihistamines; Atypical antipsychotics; Buspirone; Caffeine; CBD; Dopamine agonists; DXM; Glutamate modulator; Huperzine A; Ibogaine; and 11 more, see full page
Caution (17)
See full page: psychedex.org/substances/o-pce
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/o-pce · Version r1 · Not medical adviceValues as of
On the printout