Naloxone Facts
Opioid;
Dose and durationby route · individual sensitivity varies
Oral(mg)
Threshold< 4 mgLight4 – 8 mgCommon8 – 16 mgStrong16 – 28 mgHeavy28+ mg
Starts in 5 – 15 minLasts 1 – 2 hoursAfter-effects 1 – 12 hours
Also recorded: Insufflated · Intravenous · Intramuscular. See full page: psychedex.org/substances/naloxone
Body and dependence
- Acute toxicity
- Negligible
- Chronic toxicity
- Negligible
- Physical dependence
- None
- Psychological dependence
- None
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- None
- Fully resets after
- Not recorded
Effectslikely at a common dose
- Perception
- none likely · 2 possible
- Body
- Nausea;
Diarrhea; Excessive sweating; Pupil dilation; Restlessness; +20 possible, including Temperature dysregulation, Vomiting, Dehydration sensation - Thinking
- none likely · 4 possible, including Confusion
- Feeling
- Anxiety;
Dysphoria; +6 possible, including Anhedonia, Depression, Emotional lability - Self
- Craving;
+3 possible, including Social disconnection
Who shouldn't take it
Absolute
Hypersensitivity to naloxone
Relative
Cardiovascular disease;
Combinations60 recorded
Dangerous (10)
Anticholinergics;
Caution (32)
See full page: psychedex.org/substances/naloxone
Not graded (18)
Not listed never means safe.
Seek help immediately if
No emergency profile is recorded for this substance. Not recorded never means no risk.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
psychedex.org/substances/naloxone · Version r1 · Not medical adviceValues as of