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Modafinil Facts

Stimulant; Eugeroic; Benzhydryl; Dopamine reuptake inhibitor

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 25 mgLight50 – 100 mgCommon100 – 200 mgStrong200 – 400 mgHeavy400+ mg

Starts in 20 – 60 minLasts 5 – 10 hoursAfter-effects 6 – 16 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Slow
Fully resets after
Not recorded
Carries over to
armodafinil; adrafinil

Effectslikely at a common dose

Body
Stimulation; Wakefulness; +6 possible, including Insomnia, Dehydration sensation, Headache
Feeling
none likely · 1 possible, including Anxiety
Awareness
Sustained attention (vicara); +1 possible

Who shouldn't take it

Absolute
Known hypersensitivity to modafinil or armodafinil; Pregnancy
Relative
Pre-existing cardiovascular disease; Psychotic disorders; Bipolar disorder; Severe hepatic impairment; Renal insufficiency; Pediatric use

Combinations62 recorded

Lethal (2)
Ibogaine; Tramadol
Dangerous (29)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines, Barbiturates; Ephedrine, Pseudoephedrine; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SSRIs; Stimulants; Anticholinergics; Antipsychotics; Buspirone; Caffeine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ketamine, DXM, PCP; Lithium; NSAIDs; and 5 more, see full page
Caution (28)
See full page: psychedex.org/substances/modafinil
Not graded (3)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/modafinil · Version r1 · Not medical adviceValues as of
On the printout