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Mirtazapine Facts

Antidepressant; Sedative; Piperazinoazepine; Alpha-2 adrenergic receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 3.5 mgLight70 – 130 mgCommon130 – 190 mgStrong190 – 250 mgHeavy250+ mg

Starts in 15 – 30 minLasts 14 – 24 hours

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Not assessed
Psychological dependence
Not assessed
Withdrawal
Not assessed
Compulsive redosing
Not assessed

Tolerance

Builds
Almost immediately after ingestion
Fully resets after
7 days

Effectslikely at a common dose

Perception
Visual drifting; +9 possible, including Vestibular distortion, Visual acuity suppression, Visual haze / noise
Body
none likely · 9 possible, including Motor control impairment, Dizziness
Thinking
none likely · 4 possible, including Analysis suppression
Feeling
none likely · 3 possible
Time
none likely · 1 possible

Who shouldn't take it

None recorded. Not listed never means safe to take.

Combinations60 recorded

Dangerous (27)
Anticholinergics; Antipsychotics; Benzodiazepines, Barbiturates; Buprenorphine, Kratom; DXM; GHB, GBL; MAOIs; MDMA, Amphetamines; MDMA, MDA; NRIs; Opioids; Stimulants; Amphetamines; Atypical antipsychotics; Buspirone; Clonidine, Guanfacine; Gabapentin, Pregabalin; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; NDRIs (Wellbutrin); Poppers, Nitrates; Salvia, Ibogaine; and 3 more, see full page
Caution (25)
See full page: psychedex.org/substances/mirtazapine
Not graded (8)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice
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