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MiPT Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

MiPT (N-methyl-N-isopropyltryptamine) is a synthetic psychedelic of the tryptamine class. It partially activates serotonin receptors in the brain, producing the introspective and cognitive shifts characteristic of classical psychedelics.[1]

Subjective effects include color brightening, auditory enhancement, flowing introspective thought, and entheogenic ideation.[2][3] The experience is defined by cognitive intensity rather than visual spectacle — clear and introspective, with remarkably little of the geometric patterning typical of tryptamines.

MiPT does not produce physical dependence, and no human toxicity data exist.[4] The greatest danger is combining it with MAOIs or other serotonergic drugs, which can dramatically amplify its effects and trigger a life-threatening overheating and seizure response.[5]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight5 – 10 mgCommon10 – 20 mgStrong20 – 25 mgHeavy25+ mg

Starts in 15 – 30 minLasts 3 – 4 hoursAfter-effects 1 – 2 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Negligible
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; DMT; mescaline; 5-MeO-MiPT; 4-HO-MiPT; DPT

Effectslikely at a common dose

Perception
none likely · 31 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion
Body
Stimulation; Pupil dilation; Body scan awareness; +26 possible, including Nausea, Muscle tension, Heart rate perception changes
Thinking
Thought connectivity; +34 possible, including Suggestibility enhancement, Memory suppression, Cognitive impairment
Feeling
none likely · 9 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 9 possible, including Derealization, Communication suppression, Depersonalization
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 4 possible

Who shouldn't take it

Absolute
Psychotic disorders; Bipolar disorder; Pregnancy; MAOI use; Lithium use
Relative
Cardiovascular disease; Hepatic impairment; SSRI/SNRI use

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (19)
MDMA, MDA; Alpha-2 adrenergic receptor antagonist; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); NRIs; Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/mipt
Not graded (4)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB (2014) Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. — Psychopharmacology doi:10.1007/s00213-014-3557-7
  2. [2]
    ^Repke DB, Grotjahn DB, Shulgin AT (1985) Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents. — Journal of Medicinal Chemistry PMID:4009612
  3. [3]
    ^Shulgin (1997) TiHKAL: Tryptamines I Have Known and Loved
  4. [4]
    ^de la Fuente Revenga M, Jaster AM, McGinn J, Silva G, Saha S, Gonzalez-Maeso J (2022) Tolerance and Cross-Tolerance among Psychedelic and Nonpsychedelic 5-HT2A Receptor Agonists in Mice — ACS Chemical Neuroscience doi:10.1021/acschemneuro.2c00170
  5. [5]
    ^Malcolm B, Thomas K (2022) Serotonin toxicity of serotonergic psychedelics — Psychopharmacology doi:10.1007/s00213-021-05876-x
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