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Psychedex
Facts label

Methoxetamine Facts

Dissociative; Arylcyclohexylamine; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight10 – 25 mgCommon25 – 45 mgStrong45 – 70 mgHeavy70+ mg

Starts in 20 – 45 minLasts 4 – 6 hoursAfter-effects 4 – 12 hours

Also recorded: Insufflated. See full page: psychedex.org/substances/methoxetamine

Body and dependence

Acute toxicity
High
Chronic toxicity
High
Physical dependence
Low
Psychological dependence
Moderate
Withdrawal
Mild
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
ketamine; phencyclidine; dextromethorphan; nitrous oxide

Effectslikely at a common dose

Perception
Spatial disorientation; Music enhancement; Perspective distortion; Proprioceptive distortion; Sensory deprivation; +10 possible, including Visual acuity suppression, Double vision, Vestibular distortion
Body
Spontaneous body sensations; Motor control impairment; Pain suppression; Dizziness; Sedation; Body high; Nystagmus (eye wobbles); +9 possible, including Nausea
Thinking
Cognitive euphoria; Memory suppression; Cognitive impairment; Decision impairment; Information processing suppression; +15 possible, including Analysis suppression, Compulsive redosing urge, Confusion
Feeling
Euphoria; +2 possible
Self
Depersonalization; Derealization; +5 possible, including Communication suppression, Craving, Social disconnection
Time
Time alteration; Temporal disorientation; +1 possible
Transpersonal
none likely · 1 possible
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Cardiac conduction disorders; Epilepsy; Psychotic disorders; Pregnancy; Concurrent serotonergic medications
Relative
Hepatic impairment; Renal impairment; Urological disease

Combinations64 recorded

Lethal (4)
Alcohol; GHB, GBL; Tramadol; αMT
Dangerous (39)
Benzodiazepines; Benzodiazepines, Barbiturates; Buprenorphine, Kratom; Naltrexone; NSAIDs; Opioids; Stimulants; THC; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Amphetamines; Anticholinergics; Antihistamines; Antipsychotics; Atypical antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; DXM; Ephedrine, Pseudoephedrine; Gabapentin, Pregabalin; GHB, Baclofen; Ibogaine; and 15 more, see full page
Caution (18)
See full page: psychedex.org/substances/methoxetamine
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Severe disorientation; unable to move or speak (deep dissociation / "k-hole")
  • Complete loss of coordination — cannot stand or walk safely
  • Vomiting while incapacitated (choking / aspiration risk)
  • Very high blood pressure; fast heart rate
  • Slow or shallow breathing at high doses (especially mixed with depressants)
  • Unconsciousness; rarely, seizures

What to do

  1. Move them somewhere safe, away from stairs, water, roads, and sharp edges — they cannot protect themselves
  2. Place in the recovery position if vomiting or unconscious (aspiration is a key risk)
  3. Stay with them and reassure calmly; keep the environment quiet
  4. If breathing is slow/shallow or they are unresponsive, call emergency services
  5. Do not let them wander; do not leave them alone
  6. Be ready to give rescue breaths / CPR

Effects wear off with time in a safe, monitored setting. The main dangers are physical injury and aspiration while incapacitated, and respiratory depression when combined with other depressants — not the dissociation itself.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/methoxetamine · Version r1 · Not medical adviceValues as of
On the printout