Methallylescaline Facts
Psychedelic;
Description
Methallylescaline (MAL) is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the visual and introspective shifts characteristic of classical psychedelics.[1]
Subjective effects include color enhancement, geometric visual patterns, introspective depth, tactile enhancement, and body load.[2][3] The experience carries mescaline's warm visual saturation and introspective warmth at a fraction of the dose.
MAL produces no physical dependence, and the toxic dose in humans is unknown.[4] The defining risk is a steep dose-response curve — small increases in dose produce disproportionate jumps in intensity.[3]
Dose and durationby route · individual sensitivity varies
Starts in 20 – 60 minLasts 8 – 16 hoursAfter-effects 4 – 8 hours
Body and dependence
- Acute toxicity
- Low
- Chronic toxicity
- Not assessed
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DOx compounds; other 5-HT2A agonists
Effectslikely at a common dose
- Perception
- Color enhancement;
Color alteration; Music enhancement; Geometry; +27 possible, including Spatial disorientation, Visual haze / noise, Vestibular distortion - Body
- Pupil dilation;
Stimulation; +26 possible, including Nausea, Muscle tension, Heart rate perception changes - Thinking
- Novelty enhancement;
Aesthetic enhancement; +27 possible, including Suggestibility enhancement, Memory suppression, Thought loops - Feeling
- Emotional enhancement;
+7 possible, including Emotional lability, Anxiety, Paranoia - Self
- none likely · 9 possible, including Derealization, Depersonalization
- Time
- Time alteration;
+3 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 4 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]^Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021) Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines — Frontiers in Pharmacology doi:10.3389/fphar.2021.794254
- [2]
- [3]
- [4]