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MET Facts

Psychedelic; Substituted tryptamine; Serotonin 2A receptor agonist

Description

MET (N-methyl-N-ethyltryptamine) is a synthetic psychedelic of the tryptamine class. It activates serotonin receptors in the brain, disrupting normal sensory filtering and producing the perceptual and cognitive shifts characteristic of classical psychedelics.[1]

Subjective effects include geometric visual patterns, color enhancement, euphoria, time alteration, and a buzzing physical energy throughout the experience. The overall character is stimulating and grounded — more energized than DMT and without DMT's immersive perceptual overwhelm, with a persistent physical buzz defining the dose range.

MET does not produce physical dependence, and no lethal dose has been established in any species.[2] The primary risks are psychological — panic, paranoia, and psychotic reactions — amplified by the compound's stimulating character; combining it with monoamine oxidase inhibitors or lithium creates risk of life-threatening serotonin overload or seizures.[3]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 40 mgLight60 – 120 mgCommon120 – 150 mgStrong150 – 200 mgHeavy200+ mg

Starts in 1 – 2 hoursLasts 4 – 6 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
DMT; psilocybin; LSD; mescaline; serotonergic psychedelics

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Geometry; +30 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion
Body
Pupil dilation; Body high; +27 possible, including Dizziness, Heart rate perception changes, Motor control impairment
Thinking
none likely · 32 possible, including Confusion, Cognitive impairment, Memory suppression
Feeling
none likely · 8 possible, including Emotional lability, Anxiety, Paranoia
Self
none likely · 9 possible, including Derealization, Depersonalization, Communication suppression
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
none likely · 3 possible

Who shouldn't take it

Absolute
Schizophrenia or psychotic disorders (personal or family history); MAOIs (all types); Lithium carbonate
Relative
Cardiovascular disease or uncontrolled hypertension; Bipolar disorder; Pregnancy and lactation; Tramadol; SSRIs / SNRIs

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (17)
Dopamine agonists; Lithium; MDMA, MDA; NRIs; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (38)
See full page: psychedex.org/substances/met
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Glennon RA, Teitler M, Sanders-Bush E (1992) Hallucinogens and serotonergic mechanisms — NIDA Research Monograph PMID:1435968
  2. [2]
    ^Tittarelli R, Mannocchi G, Pantano F, Romolo FS (2015) Recreational use, analysis and toxicity of tryptamines. — Current neuropharmacology doi:10.2174/1570159x13666141210222409
  3. [3]
    ^Malcolm B, Thomas K (2022) Serotonin toxicity of serotonergic psychedelics — Psychopharmacology doi:10.1007/s00213-021-05876-x
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