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Psychedex
Facts label

Mescaline Facts

Psychedelic; Substituted phenethylamine; Serotonin 2A receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 50 mgLight100 – 200 mgCommon200 – 400 mgStrong400 – 600 mgHeavy600+ mg

Starts in 20 – 45 minLasts 6 – 14 hoursAfter-effects 6 – 36 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Negligible
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; DMT; 2C-B

Effectslikely at a common dose

Perception
Color enhancement; Visual drifting; Color alteration; Music enhancement; Geometry; Visual breathing; +29 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Stimulation; Pupil dilation; Nausea; Wakefulness; Body scan awareness; +37 possible, including Insomnia, Vomiting, Muscle tension
Thinking
Pattern recognition enhancement; Novelty enhancement; Aesthetic enhancement; Introspection enhancement; +33 possible, including Suggestibility enhancement, Cognitive impairment, Decision impairment
Feeling
Emotional enhancement; +8 possible, including Anxiety, Emotional lability, Dysphoria
Self
none likely · 9 possible, including Derealization, Depersonalization
Time
Time alteration; +3 possible, including Temporal disorientation
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +3 possible

Who shouldn't take it

Absolute
Psychotic disorders; Family history of psychosis; Pregnancy and breastfeeding; Concurrent MAO inhibitor use; Concurrent lithium use
Relative
Uncontrolled hypertension; Cardiovascular disease; Bipolar disorder

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (18)
MDMA, MDA; NRIs; Buspirone; Dopamine agonists; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (37)
See full page: psychedex.org/substances/mescaline
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/mescaline · Version r1 · Not medical adviceValues as of
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