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Psychedex
Facts label

Memantine Facts

Dissociative; Nootropic; Adamantane; NMDA receptor antagonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 10 mgLight30 – 70 mgCommon70 – 110 mgStrong110 – 170 mgHeavy170+ mg

Starts in 30 – 180 minLasts 18 – 36 hoursAfter-effects 8 – 24 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
Negligible
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
None
Fully resets after
Not recorded
Carries over to
ketamine; dextromethorphan; PCP; nitrous oxide; MXE

Effectslikely at a common dose

Perception
none likely · 11 possible, including Spatial disorientation, Vestibular distortion, Visual acuity suppression
Body
none likely · 15 possible, including Dizziness, Motor control impairment, Nausea
Thinking
none likely · 17 possible, including Cognitive impairment, Confusion, Decision impairment
Feeling
none likely · 5 possible, including Anxiety, Dysphoria
Self
none likely · 6 possible, including Depersonalization, Derealization, Communication suppression
Time
none likely · 2 possible, including Temporal disorientation
Awareness
none likely · 1 possible

Who shouldn't take it

Absolute
Memantine hypersensitivity
Relative
Pre-existing cardiovascular conditions; Concurrent CNS depressant use; Concurrent NMDA antagonist use; Seizure history or lowered seizure threshold; Severe renal impairment; Conditions or drugs producing alkaline urine

Combinations61 recorded

Lethal (1)
GHB, GBL
Dangerous (30)
Antihistamines; Benzodiazepines; Benzodiazepines, Barbiturates; Buprenorphine, Kratom; Naltrexone; NSAIDs; Opioids; THC; Anticholinergics; Antipsychotics; Buspirone; Clonidine, Guanfacine; Dopamine agonists; Gabapentin, Pregabalin; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; and 6 more, see full page
Caution (24)
See full page: psychedex.org/substances/memantine
Not graded (6)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/memantine · Version r1 · Not medical adviceValues as of
On the printout