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Psychedex
Facts label

MDAI Facts

Entactogen; Aminoindane; Serotonin releasing agent

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 40 mgLight75 – 100 mgCommon100 – 175 mgStrong175 – 250 mgHeavy250+ mg

Starts in 20 – 60 minLasts 3 – 5 hoursAfter-effects 4 – 24 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
None
Psychological dependence
Low
Withdrawal
None recorded
Compulsive redosing
Low

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
MDMA; MDA; 6-APB; 5-MAPB; 5-APB; methylone

Effectslikely at a common dose

Perception
Music enhancement; +7 possible, including Visual haze / noise
Body
Pupil dilation; Body high; +21 possible, including Temperature dysregulation, Insomnia, Bruxism
Thinking
none likely · 15 possible, including Cognitive impairment, Compulsive redosing urge, Decision impairment
Feeling
Empathy enhancement; +7 possible, including Depression, Anhedonia
Self
Sociability enhancement; Social connection; +4 possible
Time
none likely · 2 possible
Awareness
none likely · 2 possible

Who shouldn't take it

Absolute
Pregnancy and lactation; MAOI use; Concurrent serotonergic drug use
Relative
Hypertension; Epilepsy; Psychotic disorders; Hepatic impairment

Combinations61 recorded

Lethal (2)
MAOIs; Tramadol
Dangerous (32)
Amphetamines; Atypical antipsychotics; Dopamine agonists; Lithium; Local anesthetics; MDMA, Amphetamines; NRIs; Opioids; Psychedelics; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Anticholinergics; Antihistamines; Antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; DXM; Ephedrine, Pseudoephedrine; GHB, Baclofen; GHB, GBL; and 8 more, see full page
Caution (23)
See full page: psychedex.org/substances/mdai
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Overheating / very high body temperature — heavy sweating, then hot dry skin (the leading cause of MDMA deaths, worse when dancing in hot venues)
  • Muscle rigidity, jaw clenching, tremor, or twitching (possible serotonin syndrome)
  • Fast, pounding heartbeat; chest pain
  • Agitation, confusion; seizures
  • Hyponatremia (water intoxication) — headache, confusion, drowsiness, vomiting, and seizures from drinking too much water
  • Nausea/vomiting; collapse or unconsciousness

What to do

  1. Move them somewhere cool and help them cool down — overheating is the main danger
  2. Sip water to stay hydrated but DO NOT overdrink — roughly a cup (250 ml) per hour if active; too much water can be deadly (hyponatremia)
  3. Get them to rest and stop dancing
  4. For overheating, seizures, chest pain, muscle rigidity/tremor, confusion, or unresponsiveness, call emergency services
  5. Recovery position if drowsy or vomiting; stay with them
  6. Be ready to give rescue breaths / CPR

Most resolve with cooling, rest, sensible hydration, and time. The life-threatening dangers are hyperthermia, serotonin syndrome, and hyponatremia (too much water) — each a medical emergency, not something to wait out.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/mdai · Version r1 · Not medical adviceValues as of
On the printout