Skip to main content
Psychedex
Article

LSZ Facts

Psychedelic; Lysergamide; Serotonin 2A receptor agonist

Description

LSZ (lysergic acid 2,4-dimethylazetidide) — Diazedine, Lambda — is a semi-synthetic psychedelic of the lysergamide class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.[1]

Subjective effects include geometric visual patterns, color enhancement, time alteration, thought acceleration, and ego dissolution. The experience closely resembles LSD — a broad shift across perception and cognition — though possibly shorter and slightly less analytically stimulating.

LSZ does not produce physical dependence, and no lethal dose has been established.[2] The primary danger is psychological — dose-dependent anxiety and ego dissolution can escalate to panic, with highest risk for those predisposed to psychotic disorders.[3]

Dose and durationby route · individual sensitivity varies

Oral(µg)
Threshold< 50 µgLight100 – 150 µgCommon150 – 300 µgStrong300 – 400 µgHeavy400+ µg

Starts in 20 – 45 minLasts 6 – 10 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
Negligible
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Rapid
Fully resets after
7 days
Carries over to
LSD; psilocybin; mescaline; DMT; other serotonergic psychedelics

Effectslikely at a common dose

Perception
Visual drifting; Depth perception distortion; Perspective distortion; Symmetrical texture repetition; Music enhancement; Touch enhancement; Visual morphing; Color alteration; Color enhancement; Tracers; After-images; Brightness alteration; Environmental patterning; Geometry; Holotropic state; Light sensitivity; Sound sensitivity; Visual breathing; +18 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion
Body
Pupil dilation; Spontaneous body sensations; Stimulation; Wakefulness; Appetite suppression; Body high; Body scan awareness; Insomnia; +28 possible, including Nausea, Heart rate perception changes, Vasoconstriction
Thinking
Conceptual thinking; Creativity enhancement; Immersion enhancement; Novelty enhancement; Thought acceleration; Thought loops; Pattern recognition enhancement; Aesthetic enhancement; Cognitive euphoria; Cognitive flexibility; Increased nature relatedness; Introspection enhancement; Multiple thought streams; Openness enhancement; Suggestibility enhancement; Thought connectivity; +21 possible, including Thought disorganization, Memory suppression, Decision impairment
Feeling
Emotional enhancement; Emotional lability; Euphoria; Simultaneous emotions; +4 possible, including Anxiety, Paranoia
Self
Derealization; Emotional susceptibility; +11 possible, including Depersonalization, Communication suppression, Ego inflation
Time
Time alteration; Present-moment absorption; Temporal disorientation; +2 possible
Transpersonal
none likely · 1 possible
Awareness
Personal insight; +6 possible

Who shouldn't take it

Absolute
Concurrent lithium therapy; Psychotic disorders; Bipolar disorder; Pregnancy; Concurrent tramadol use
Relative
Severe cardiovascular disease; Epilepsy

Combinations61 recorded

Lethal (1)
MAOIs
Dangerous (17)
Dopamine agonists; Lithium; MDMA, MDA; NRIs; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; MDMA, Amphetamines; NDRIs (Wellbutrin); Psychedelics; Salvia, Ibogaine; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids
Caution (38)
See full page: psychedex.org/substances/lsz
Not graded (5)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Colestock T, Burrow TE, Chapman SJ, Stratford A, Nichols DE, Halberstadt AL (2017) Return of the lysergamides. Part II: Analytical and behavioural characterization of N6-allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ) — Drug Testing and Analysis doi:10.1002/dta.1985
  2. [2]
    ^Schlag AK, Aday J, Salam I, Neill JC, Nutt DJ (2022) Adverse effects of psychedelics: From anecdotes and misinformation to systematic science — Journal of Psychopharmacology doi:10.1177/02698811211069100
  3. [3]
    ^Halpern JH, Lerner AG, Passie T (2018) A Review of Hallucinogen Persisting Perception Disorder (HPPD) and an Exploratory Study of Subjects Claiming Symptoms of HPPD — Current Topics in Behavioral Neurosciences doi:10.1007/7854_2016_457
Print version
Report an issue