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Psychedex
Facts label

Kratom Facts

Opioid; Stimulant; Indole alkaloid; Mu-opioid receptor partial agonist

Dose and duration

No dose or duration recorded for any route.

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
High
Psychological dependence
High
Withdrawal
Moderate
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
10 days
Carries over to
opioids

Who shouldn't take it

Absolute
Pre-existing liver disease; Pregnancy and lactation; Concurrent opioid use; Concurrent CNS depressants
Relative
Respiratory compromise; History of psychosis; Renal impairment; CYP3A4 substrates with narrow therapeutic index

Combinations65 recorded

Lethal (5)
Alcohol; GBL; GHB; Ketamine; Tramadol
Dangerous (23)
Alpha-2 adrenergic receptor antagonist; Anticholinergics; Benzodiazepines, Barbiturates; Gabapentin, Pregabalin; GHB, Baclofen; Opioids; Poppers (Alkyl nitrites); Poppers, Nitrates; Antipsychotics; Atypical antipsychotics; Benzodiazepines; DXM; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; Local anesthetics; MAOIs; MDMA, MDA; NDRIs (Wellbutrin); SNRIs; SSRIs; Synthetic cannabinoids; Salvia, Ibogaine
Caution (28)
See full page: psychedex.org/substances/kratom
Not graded (9)
Not listed never means safe.

Seek help immediately if

  • Unresponsive / can't be woken, even to a firm sternal rub
  • Slow, shallow, or stopped breathing
  • Pinpoint pupils
  • Blue/grey lips, fingertips, or skin (cyanosis)
  • Limp body; pale, clammy skin
  • Choking or gurgling sounds ("death rattle")
  • Slow, erratic, or absent pulse

What to do

  1. Try to wake them — shout their name, firm sternal rub
  2. Call emergency services immediately
  3. Administer naloxone if available
  4. Give rescue breaths (or CPR if there is no pulse)
  5. Place them in the recovery position
  6. Stay with them; re-dose naloxone every 2–3 minutes if there is no response
Reversal agent
Naloxone (Narcan) — opioid antagonist. May require repeated doses; its effect can wear off before the opioid does.

With prompt naloxone and rescue breathing, reversal is usually rapid. Because naloxone can wear off before the opioid — especially with long-acting opioids (methadone) or high-potency ones (fentanyl) — a period of monitoring is needed even after the person revives.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/kratom · Version r2 · Not medical adviceValues as of