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Psychedex
Facts label

Kava Facts

Depressant; Anxiolytic; Lactone; GABA-A receptor positive allosteric modulator

Dose and duration

No dose or duration recorded for any route.

Body and dependence

Acute toxicity
Low
Chronic toxicity
Moderate
Physical dependence
Low
Psychological dependence
Low
Withdrawal
Severe · medical supervision
Compulsive redosing
Low

Tolerance

Builds
None
Fully resets after
Not recorded
Carries over to
benzodiazepines; alcohol

Effectslikely at a common dose

Perception
none likely · 5 possible, including Spatial disorientation, Vestibular distortion
Body
Muscle relaxation; Tingling / electric sensations; +10 possible, including Motor control impairment, Dizziness, Nausea
Thinking
none likely · 7 possible, including Cognitive impairment, Decision impairment, Information processing suppression
Feeling
Anxiety suppression; +1 possible
Self
none likely · 5 possible

Who shouldn't take it

Absolute
Pre-existing liver disease; Concurrent heavy alcohol use; Pregnancy and lactation; Children and adolescents; Concurrent benzodiazepine use
Relative
CYP2D6 poor metabolizer phenotype; Narrow therapeutic index drugs metabolized by CYP2C9/CYP2C19; Concurrent CNS depressants (opioids, sedating antihistamines)

Combinations60 recorded

Lethal (2)
Ibogaine; Opioids
Dangerous (40)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Ephedrine, Pseudoephedrine; Gabapentin, Pregabalin; Local anesthetics; MAOIs; MDMA, Amphetamines; MDMA, MDA; Naltrexone; Nicotine; NRIs; Stimulants; 5-HTP, Tryptophan; Anticholinergics; Antihistamines; Antipsychotics; Atypical antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; and 16 more, see full page
Caution (15)
See full page: psychedex.org/substances/kava
Not graded (3)
Not listed never means safe.

Seek help immediately if

No emergency profile is recorded for this substance. Not recorded never means no risk.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/kava · Version r2 · Not medical adviceValues as of
On the printout