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Psychedex
Facts label

Isotonitazene Facts

Opioid; Depressant; Mu-opioid receptor agonist

Dose and durationby route · individual sensitivity varies

Insufflated(μg)
Threshold< 5 μgLight5 – 15 μgCommon15 – 40 μgStrong40 – 80 μgHeavy80+ μg

Starts in 1 – 5 minLasts 1 – 3 hoursAfter-effects 2 – 8 hours

Body and dependence

Acute toxicity
Critical
Chronic toxicity
Moderate
Physical dependence
High
Psychological dependence
High
Withdrawal
Severe · medical supervision
Compulsive redosing
High

Tolerance

Builds
Rapid
Fully resets after
14 days
Carries over to
morphine; fentanyl; heroin; oxycodone; hydromorphone; methadone; all MOR full agonists

Effectslikely at a common dose

Perception
none likely · 4 possible, including Visual acuity suppression, Spatial disorientation, Vestibular distortion
Body
Bodily heaviness; Muscle relaxation; Body high; Breathing alteration; Constipation; Motor control impairment; Pain suppression; Physical fatigue; Pupil constriction; Respiratory depression; Sedation; +14 possible, including Nausea, Dizziness, Excessive sweating
Thinking
Cognitive euphoria; Cognitive fatigue; Cognitive impairment; Focus suppression; +9 possible, including Analysis suppression, Compulsive redosing urge, Decision impairment
Feeling
Euphoria; +3 possible, including Dysphoria
Self
none likely · 5 possible, including Craving, Communication suppression, Social disconnection
Time
none likely · 2 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Respiratory compromise; Concurrent benzodiazepine use; Concurrent opioid use; Concurrent alcohol use; Concurrent MAOI use
Relative
Hepatic impairment; Renal impairment

Combinations60 recorded

Lethal (4)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Local anesthetics
Dangerous (28)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Anticholinergics; Antihistamines; Antipsychotics; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; MAOIs; MDMA, Amphetamines; MDMA, MDA; Naltrexone; NRIs; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids; THC; Caffeine; CBD; Glutamate modulator; Huperzine A; and 4 more, see full page
Caution (19)
See full page: psychedex.org/substances/isotonitazene
Not graded (9)
Not listed never means safe.

Seek help immediately if

  • Unresponsive / can't be woken, even to a firm sternal rub
  • Slow, shallow, or stopped breathing
  • Pinpoint pupils
  • Blue/grey lips, fingertips, or skin (cyanosis)
  • Limp body; pale, clammy skin
  • Choking or gurgling sounds ("death rattle")
  • Slow, erratic, or absent pulse

What to do

  1. Try to wake them — shout their name, firm sternal rub
  2. Call emergency services immediately
  3. Administer naloxone if available
  4. Give rescue breaths (or CPR if there is no pulse)
  5. Place them in the recovery position
  6. Stay with them; re-dose naloxone every 2–3 minutes if there is no response
Reversal agent
Naloxone (Narcan) — opioid antagonist. May require repeated doses; its effect can wear off before the opioid does.

With prompt naloxone and rescue breathing, reversal is usually rapid. Because naloxone can wear off before the opioid — especially with long-acting opioids (methadone) or high-potency ones (fentanyl) — a period of monitoring is needed even after the person revives.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/isotonitazene · Version r1 · Not medical adviceValues as of
On the printout