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Hexedrone Facts

Stimulant; Substituted cathinone; Norepinephrine-dopamine reuptake inhibitor

Description

Hexedrone (2-(methylamino)-1-phenylhexan-1-one) is a synthetic stimulant of the cathinone class. It blocks the brain's dopamine and norepinephrine recycling mechanisms, producing focused stimulation and euphoria.[1][2]

Subjective effects include euphoria, focus enhancement, thought acceleration, and a strong compulsive redosing urge.[3] The experience is narrowly stimulant — dopamine-driven, without the warmth of mixed cathinones like mephedrone.

Dependence liability is moderate to high — potent dopamine blockade drives compulsive redosing that can escalate into binge use.[4] The safety margin is narrow: fatal and non-fatal blood concentrations in N-ethyl structural analog cases were not far apart.[5][6]

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 30 mgLight50 – 70 mgCommon70 – 100 mgStrong100 – 125 mgHeavy125+ mg

Starts in 15 – 30 minLasts 1 – 4 hoursAfter-effects 1 – 12 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
Moderate
Withdrawal
Moderate
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
10.5 days
Carries over to
amphetamines; cocaine; cathinones; dopaminergic stimulants

Effectslikely at a common dose

Perception
none likely · 6 possible
Body
Appetite suppression; Dry mouth; Insomnia; Pupil dilation; Stimulation; Vasoconstriction; Wakefulness; +20 possible, including Excessive sweating, Heart rate perception changes, Muscle tension
Thinking
Cognitive euphoria; Thought acceleration; +19 possible, including Compulsive redosing urge, Cognitive dysphoria, Cognitive impairment
Feeling
Euphoria; +7 possible, including Anxiety, Anhedonia, Depression
Self
none likely · 8 possible, including Craving, Ego inflation, Compulsive repetitive behavior
Time
none likely · 1 possible
Awareness
Sustained attention (vicara); +1 possible

Who shouldn't take it

Absolute
Cardiovascular disease; Pregnancy and lactation; Concurrent MAOI use
Relative
Seizure disorders; Psychotic spectrum and mood disorders; Renal impairment

Combinations60 recorded

Lethal (1)
MAOIs
Dangerous (31)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Ephedrine, Pseudoephedrine; GHB, GBL; Local anesthetics; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Stimulants; 5-HTP, Tryptophan; Anticholinergics; Antipsychotics; Buspirone; Caffeine; Clonidine, Guanfacine; Dopamine agonists; DXM; GHB, Baclofen; Ibogaine; Ketamine, DXM, PCP; Lithium; NSAIDs; Opioids; Poppers (Alkyl nitrites); and 7 more, see full page
Caution (24)
See full page: psychedex.org/substances/hexedrone
Not graded (4)
Not listed never means safe.

Seek help immediately if

  • Chest pain; racing, pounding, or irregular heartbeat
  • Very high body temperature; heavy sweating; hot, flushed skin
  • Severe agitation, paranoia, panic, or confusion
  • Severe headache; muscle rigidity or twitching
  • Seizures
  • Signs of stroke — face drooping, one-sided weakness, slurred speech
  • Difficulty breathing; collapse or unconsciousness

What to do

  1. Call emergency services for chest pain, overheating, seizure, or unresponsiveness
  2. Move them to a cool, quiet place and reduce stimulation
  3. Cool the body — remove excess clothing, apply cool damp cloths, fan them
  4. Keep them calm; reassure — panic worsens the cardiovascular strain
  5. If seizing, protect from injury (don't restrain); recovery position afterward
  6. Monitor breathing and be ready to give rescue breaths / CPR

Most stimulant overdoses settle with cooling, a calm environment, and time. The medical danger is hyperthermia, cardiac events (arrhythmia, heart attack, stroke), and seizures — get help immediately if any appear.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

Version r1 · Not medical advice

References

  1. [1]
    ^Kolaczynska KE, Thomann J, Hoener MC, Liechti ME (2021) The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. — International journal of molecular sciences doi:10.3390/ijms22158277
  2. [2]
    ^Persson M, Vikingsson S, Kronstrand R, Green H (2024) Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method. — Drug Testing and Analysis doi:10.1002/dta.3547
  3. [3]
    ^PsychonautWiki / KnowDrugs community consensus (2024) Hexedrone dose and tolerance data (user-consensus) Link
  4. [4]
    ^Lefeuvre S, Richeval C, Lelong J, Venisse N, Humbert L, Brunet B (2024) N-Ethylhexedrone: A very long and bad trip! A case series — Journal of Analytical Toxicology doi:10.1093/jat/bkae040
  5. [5]
    ^Kovács K, Kereszty É, Berkecz R, Tiszlavicz L, et al. (2019) Fatal intoxication of a regular drug user following N-ethyl-hexedrone and ADB-FUBINACA consumption — Journal of Forensic and Legal Medicine doi:10.1016/j.jflm.2019.04.012
  6. [6]
    ^Domagalska E, Banaszkiewicz L, Woźniak MK, Kata M, Szpiech B, Kaliszan M (2021) Fatal N-Ethylhexedrone Intoxication — Journal of Analytical Toxicology doi:10.1093/jat/bkaa159
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