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Psychedex
Facts label

Harmaline Facts

Psychedelic; Indole alkaloid; Monoamine oxidase inhibitor

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 25 mgLight25 – 75 mgCommon75 – 150 mgStrong150 – 300 mgHeavy300+ mg

Starts in 30 – 60 minLasts 4 – 5 hours

Body and dependence

Acute toxicity
Low
Chronic toxicity
Low
Physical dependence
None
Psychological dependence
Negligible
Withdrawal
None recorded
Compulsive redosing
Negligible

Tolerance

Builds
Moderate
Fully resets after
Not recorded
Carries over to
harmine; tetrahydroharmine; moclobemide

Effectslikely at a common dose

Perception
Sleep-transition hallucinations; +15 possible, including Spatial disorientation, Vestibular distortion, Visual haze / noise
Body
Trembling; +26 possible, including Nausea, Dizziness, Motor control impairment
Thinking
none likely · 18 possible, including Cognitive impairment, Confusion, Information processing suppression
Feeling
none likely · 8 possible, including Anxiety, Emotional lability, Dysphoria
Self
none likely · 6 possible, including Derealization, Communication suppression, Depersonalization
Time
none likely · 2 possible, including Temporal disorientation
Awareness
Lucid dreaming enhancement; +1 possible

Who shouldn't take it

Absolute
Dextromethorphan (DXM); Lithium; Triptan medications; Tricyclic antidepressants; St. John's Wort; Tramadol; SSRI therapy; SNRI therapy; MAOI therapy; Meperidine / pethidine
Relative
Cardiovascular disease; Seizure disorders; Psychotic disorder history; Hepatic impairment; CYP2D6 poor metabolizer status; Pregnancy; Tyramine-rich diet

Combinations60 recorded

Lethal (6)
Amphetamines; MDMA, Amphetamines; MDMA, MDA; Psychedelics; SNRIs; Stimulants
Dangerous (28)
5-HTP, Tryptophan; Alpha-2 adrenergic receptor antagonist; Buspirone; Ephedrine, Pseudoephedrine; Local anesthetics; NDRIs (Wellbutrin); NRIs; Opioids; SSRIs; Antihistamines; Antipsychotics; Benzodiazepines, Barbiturates; Caffeine; Cannabis; Clonidine, Guanfacine; Dopamine agonists; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; Ketamine, DXM, PCP; L-Tyrosine; Naltrexone; NSAIDs; and 4 more, see full page
Caution (20)
See full page: psychedex.org/substances/harmaline
Not graded (6)
Not listed never means safe.

Seek help immediately if

Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:

  • Very high body temperature; hot, dry skin
  • Seizures
  • Chest pain; fast or irregular heartbeat
  • Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
  • Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
  • Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm

What to do

  1. Stay calm and reassure — remind them they took a drug and the effect will pass
  2. Move to a calm, quiet, safe space with low light; reduce noise and sensory input
  3. Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
  4. Talk them down gently; don't grab or restrain unless they're in danger
  5. For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
  6. If overheating, cool the body; be ready to give rescue breaths / CPR

The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/harmaline · Version r1 · Not medical adviceValues as of
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