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Ethylmorphine Facts

Opioid; Depressant; Substituted morphinan; Mu-opioid receptor agonist

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 20 mgLight40 – 50 mgCommon50 – 100 mgStrong100 – 200 mgHeavy200+ mg

Starts in 20 – 45 minLasts 4 – 5 hoursAfter-effects 2 – 6 hours

Body and dependence

Acute toxicity
Moderate
Chronic toxicity
Moderate
Physical dependence
High
Psychological dependence
High
Withdrawal
Moderate · medical supervision
Compulsive redosing
Moderate

Tolerance

Builds
Moderate
Fully resets after
1.5 weeks
Carries over to
morphine; codeine; oxycodone; hydrocodone; heroin; all mu-opioid agonists

Effectslikely at a common dose

Perception
none likely · 4 possible, including Spatial disorientation, Visual acuity suppression
Body
Muscle relaxation; Body high; Constipation; Pain suppression; Pupil constriction; Sedation; +16 possible, including Respiratory depression, Dizziness, Motor control impairment
Thinking
none likely · 15 possible, including Cognitive impairment, Analysis suppression, Decision impairment
Self
none likely · 5 possible, including Craving, Social disconnection, Communication suppression
Time
none likely · 2 possible, including Temporal disorientation

Who shouldn't take it

Absolute
Respiratory insufficiency; Head injury or raised intracranial pressure; Pediatric patients under 8 years; Concurrent CNS depressant use; Intravenous administration; Paralytic ileus
Relative
Hepatic impairment; CYP2D6 ultrarapid metabolizer status

Combinations62 recorded

Lethal (6)
Benzodiazepines, Barbiturates; GHB, Baclofen; GHB, GBL; Ketamine; Local anesthetics; Tramadol
Dangerous (28)
Alpha-2 adrenergic receptor antagonist; Amphetamines; Anticholinergics; Antihistamines; Antipsychotics; Benzodiazepines; Buprenorphine, Kratom; Cannabis, THC; Clonidine, Guanfacine; Gabapentin, Pregabalin; MAOIs; MDMA, Amphetamines; MDMA, MDA; Naltrexone; NRIs; SNRIs; SSRIs; Stimulants; Synthetic cannabinoids; THC; Caffeine; CBD; Glutamate modulator; Huperzine A; and 4 more, see full page
Caution (19)
See full page: psychedex.org/substances/ethylmorphine
Not graded (9)
Not listed never means safe.

Seek help immediately if

  • Unresponsive / can't be woken, even to a firm sternal rub
  • Slow, shallow, or stopped breathing
  • Pinpoint pupils
  • Blue/grey lips, fingertips, or skin (cyanosis)
  • Limp body; pale, clammy skin
  • Choking or gurgling sounds ("death rattle")
  • Slow, erratic, or absent pulse

What to do

  1. Try to wake them — shout their name, firm sternal rub
  2. Call emergency services immediately
  3. Administer naloxone if available
  4. Give rescue breaths (or CPR if there is no pulse)
  5. Place them in the recovery position
  6. Stay with them; re-dose naloxone every 2–3 minutes if there is no response
Reversal agent
Naloxone (Narcan) — opioid antagonist. May require repeated doses; its effect can wear off before the opioid does.

With prompt naloxone and rescue breathing, reversal is usually rapid. Because naloxone can wear off before the opioid — especially with long-acting opioids (methadone) or high-potency ones (fentanyl) — a period of monitoring is needed even after the person revives.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/ethylmorphine · Version r1.a1 · Not medical adviceValues as of
On the printout