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Ephylone Facts

Stimulant; Entactogen; Substituted cathinone; Dopamine releasing agent

Dose and durationby route · individual sensitivity varies

Oral(mg)
Threshold< 5 mgLight10 – 20 mgCommon20 – 40 mgStrong40 – 80 mgHeavynot recorded

Starts in 15 – 30 minLasts 4 – 8 hoursAfter-effects 6 – 24 hours

Body and dependence

Acute toxicity
High
Chronic toxicity
Moderate
Physical dependence
Moderate
Psychological dependence
High
Withdrawal
Moderate
Compulsive redosing
High

Tolerance

Builds
Moderate
Fully resets after
Not recorded
Carries over to
cocaine; amphetamine; MDPV; methylone; mephedrone; eutylone

Effectslikely at a common dose

Body
Appetite suppression; Body high; Insomnia; Physical fatigue; Stimulation; Wakefulness; +22 possible, including Heart rate perception changes, Vasoconstriction, Bruxism
Thinking
none likely · 26 possible, including Compulsive redosing urge, Decision impairment, Cognitive dysphoria
Feeling
Emotional enhancement; Euphoria; +11 possible, including Anxiety, Anhedonia, Depression
Self
none likely · 9 possible, including Craving, Compulsive repetitive behavior

Who shouldn't take it

Absolute
Pre-existing cardiovascular disease; Pregnancy and lactation; MAO inhibitors
Relative
Seizure disorders; Hepatic impairment; Hyperthermia-prone conditions; Concurrent serotonergic medication

Combinations61 recorded

Lethal (2)
MAOIs; Tramadol
Dangerous (33)
Alpha-2 adrenergic receptor antagonist; Anticholinergics; Atypical antipsychotics; Caffeine; Dopamine agonists; Ephedrine, Pseudoephedrine; Local anesthetics; MDMA, Amphetamines; MDMA, MDA; NDRIs (Wellbutrin); NRIs; Opioids; SNRIs; SSRIs; Stimulants; 5-HTP, Tryptophan; Antihistamines; Antipsychotics; Buspirone; Clonidine, Guanfacine; DXM; GHB, Baclofen; GHB, GBL; Ibogaine; and 9 more, see full page
Caution (23)
See full page: psychedex.org/substances/ephylone
Not graded (3)
Not listed never means safe.

Seek help immediately if

  • Overheating / very high body temperature — heavy sweating, then hot dry skin (the leading cause of MDMA deaths, worse when dancing in hot venues)
  • Muscle rigidity, jaw clenching, tremor, or twitching (possible serotonin syndrome)
  • Fast, pounding heartbeat; chest pain
  • Agitation, confusion; seizures
  • Hyponatremia (water intoxication) — headache, confusion, drowsiness, vomiting, and seizures from drinking too much water
  • Nausea/vomiting; collapse or unconsciousness

What to do

  1. Move them somewhere cool and help them cool down — overheating is the main danger
  2. Sip water to stay hydrated but DO NOT overdrink — roughly a cup (250 ml) per hour if active; too much water can be deadly (hyponatremia)
  3. Get them to rest and stop dancing
  4. For overheating, seizures, chest pain, muscle rigidity/tremor, confusion, or unresponsiveness, call emergency services
  5. Recovery position if drowsy or vomiting; stay with them
  6. Be ready to give rescue breaths / CPR

Most resolve with cooling, rest, sensible hydration, and time. The life-threatening dangers are hyperthermia, serotonin syndrome, and hyponatremia (too much water) — each a medical emergency, not something to wait out.

988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE

psychedex.org/substances/ephylone · Version r1 · Not medical adviceValues as of
On the printout