DOPR Facts
Psychedelic;
Description
DOPR (2,5-dimethoxy-4-propylamphetamine) is a synthetic psychedelic of the phenethylamine class. It activates serotonin receptors in the brain, producing the visual and cognitive shifts characteristic of classical psychedelics.
Subjective effects include geometric visual patterns, closed-eye imagery, time alteration, and altered thinking. The experience is slow-building and extraordinarily persistent — a dream-adjacent, liminal quality between wakefulness and sleep that spans an entire day-night cycle.
DOPR does not produce physical dependence, and no lethal dose has been established[1] — but its extraordinary duration compounds physiological stress across a full day-night cycle. Class-level evidence links DOx compounds to dangerous agitation, seizures, and muscle breakdown.[2]
Dose and durationby route · individual sensitivity varies
Starts in 60 – 120 minLasts 20 – 30 hoursAfter-effects 12 – 24 hours
Body and dependence
- Acute toxicity
- Moderate
- Chronic toxicity
- Low
- Physical dependence
- None
- Psychological dependence
- Negligible
- Withdrawal
- None recorded
- Compulsive redosing
- Negligible
Tolerance
- Builds
- Rapid
- Fully resets after
- 7 days
- Carries over to
- LSD;
psilocybin; mescaline; DOM; DOC; DOB; DOI; DOET; 2C-P; 2C-B
Effectslikely at a common dose
- Perception
- Visual morphing;
Brightness alteration; Color alteration; Color enhancement; Depth perception distortion; Environmental patterning; Geometry; Music enhancement; Symmetrical texture repetition; Tracers; Visual breathing; Visual drifting; +22 possible, including Visual haze / noise, Spatial disorientation, Vestibular distortion - Body
- Appetite suppression;
Body high; Heart rate perception changes; Insomnia; Muscle tension; Physical fatigue; Pupil dilation; Spontaneous body sensations; Stimulation; Wakefulness; +22 possible, including Dehydration sensation, Excessive sweating, Nausea - Thinking
- Aesthetic enhancement;
+29 possible, including Thought loops, Suggestibility enhancement, Cognitive dysphoria - Feeling
- Emotional enhancement;
+11 possible, including Emotional lability, Anxiety, Anhedonia - Self
- none likely · 11 possible, including Derealization, Depersonalization, Ego inflation
- Time
- Time alteration;
+4 possible, including Temporal disorientation - Transpersonal
- none likely · 1 possible
- Awareness
- none likely · 3 possible
Who shouldn't take it
Combinations61 recorded
Seek help immediately if
Most difficulty is psychological (intense fear, panic, confusion) and passes with calm support — the signs below mean seek emergency help:
- Very high body temperature; hot, dry skin
- Seizures
- Chest pain; fast or irregular heartbeat
- Severe muscle rigidity, tremor, or twitching (possible serotonin syndrome)
- Cold, pale, or blue fingers/toes — severe vasoconstriction (notably NBOMe / DOx)
- Persistent vomiting; unconsciousness; uncontrollable agitation or risk of self-harm
What to do
- Stay calm and reassure — remind them they took a drug and the effect will pass
- Move to a calm, quiet, safe space with low light; reduce noise and sensory input
- Keep them from harm — they may act on fear or confusion; stay with them, don't leave them alone
- Talk them down gently; don't grab or restrain unless they're in danger
- For the medical signs above (overheating, seizure, chest pain, vasoconstriction, unresponsive) call emergency services
- If overheating, cool the body; be ready to give rescue breaths / CPR
The experience is time-limited and usually resolves with calm reassurance in a safe setting — psychological first aid, not medication. Serious physical harm is uncommon for classic psychedelics (LSD, psilocybin) but real for some potent phenethylamines (NBOMe, DOx), where hyperthermia, seizures, and vasoconstriction warrant emergency care.
988 Suicide & Crisis LifelineFireside Project: 62-FIRESIDE
References
- [1]
- [2]^Halberstadt AL (2017) Pharmacology and Toxicology of N-Benzylphenethylamine (NBOMe) Hallucinogens — Current Topics in Behavioral Neurosciences doi:10.1007/7854_2016_64